Fig. 2

Downregulated gene co-expression modules in ASD. This figure shows gene co-expression modules that were on-average decreased in ME expression in ASD and in a replicable manner across datasets. Each module has a scatter-boxplot whereby each individual is represented by a dot and the central tendency (median) and dispersion (interquartile range) is shown with the boxplot. Next to each scatter-boxplot are the process-level enrichment terms passing FDR q < 0.05 from MetaCore GeneGO. The vertical black line on the enrichment bar plots represents the p value where FDR q < 0.05. For each module, the replication Bayes Factor statistic (repBF) is cited above the scatter-boxplot (repBF >10 indicates strong evidence for replication). In the bottom right corner of this figure is a Venn diagram summarizing the common overlap between ASD-downregulated genes across both datasets