Fig. 2

Neuroanatomical differences between mutant and WT mice carrying the Mecp2^tm1Hzo truncation mutation. Neuroanatomy was analyzed on a voxelwise level across the brain and within 159 segmented anatomical regions. Coronal slices from the rostral [1] to caudal [7] partitions from the final nonlinear average depicting the neuroanatomy are shown in (a). Voxelwise differences between mutant and WT were overlaid on the final nonlinear average for the following experimental groups: b Mecp2^{308/y[B6,P60]}; t = 2.71, 10% FDR-corrected, c Mecp2^{308/y[B6,P200]}; uncorrected t = 2.52, p < 0.01, d Mecp2^{308/x[B6,P200]}; t = 2.77, 10% FDR-corrected and e. Mecp2^{308/308[B6,P200]};t = 2.64, 10% FDR-corrected. The magnitude of the effect is shown as a percent difference; Mutants > WT (red to yellow), mutants < WT (dark blue to light blue). Percent difference in volume across the 159 segmented structures are shown in (f). White barsindicate no difference, blueindicating a smaller volume in mutants compared to WT, and redindicating a larger volume in mutants relative to WT