Fig. 1

Differential effect of mutation on body weight and total brain volume of male and female Mecp2^tm1Hzo mice. a Body weight (grams) and b total brain volume (mm³) is shown for 200-day-old WT (white bar) along with hemizygous (Mecp2^{308/y[B6,P200]}, light gray), heterozygous (Mecp2^{308/x[B6,P200]}, medium gray), or homozygous (Mecp2^{308/308[B6,P200]}, dark gray) mice carrying the Mecp2^tm1Hzo allele. In order to assess the effect of the Mecp2^tm1Hzo allele during early adulthood, body weight measurements were collected from 42-day-old WT and hemizygous (Mecp2^{308/y[B6,P42]}) males, while total brain volume was measured from 60-day-old WT and hemizygous (Mecp2^{308/y[B6,P60]}) males. All mice were on a C57BL/6J background (B6). Each mutant mouse was compared to their WT matched control using a ttest with a false discovery rate threshold to control for multiple comparisons. *q < 0.05, **q < 0.01