Fig. 1From: Neuroanatomy in mouse models of Rett syndrome is related to the severity of Mecp2 mutation and behavioral phenotypesDifferential effect of mutation on body weight and total brain volume of male and female Mecp2tm1Hzo mice. a Body weight (grams) and b total brain volume (mm3) is shown for 200-day-old WT (white bar) along with hemizygous (Mecp2308/y[B6,P200], light gray), heterozygous (Mecp2308/x[B6,P200], medium gray), or homozygous (Mecp2308/308[B6,P200], dark gray) mice carrying the Mecp2tm1Hzo allele. In order to assess the effect of the Mecp2tm1Hzo allele during early adulthood, body weight measurements were collected from 42-day-old WT and hemizygous (Mecp2308/y[B6,P42]) males, while total brain volume was measured from 60-day-old WT and hemizygous (Mecp2308/y[B6,P60]) males. All mice were on a C57BL/6J background (B6). Each mutant mouse was compared to their WT matched control using a ttest with a false discovery rate threshold to control for multiple comparisons. *q < 0.05, **q < 0.01Back to article page