Fig. 1

Sign test of concordance of the direction of effect (odds ratio) of the discovery (PGC worldwide) and the replication sample (a replication set 1: iPSYCH; b replication set 2: deCODE/SEED). Blue line is the –log10(P) of the binomial sign test for all associated markers below the rank. The green line describes the concordance, and the grey markers the association in the discovery set