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Table 2 Comparison of DEGs with genes activated in M1 and M2 macrophages

From: Transcriptome analysis of microglia in a mouse model of Rett syndrome: differential expression of genes associated with microglia/macrophage activation and cellular stress

Mecp2 DEGs M1/M2 expression Shared genes p value
5 week (n = 464) M1 down 28 1.83E−04
M1 up 28 1.34E−05
M2 down 13 3.21E−02
M2 up 34 1.86E−12
24 week (n = 79) M1 down 8 2.10E−03
M1 up 6 1.44E−02
M2 down 7 2.68E−04
M2 up 8 7.90E−05
  1. DEGs in 5- and 24-week microglia identified in this study were compared with genes activated to produce M1 and M2 macrophages from a baseline state (M0) in mouse [55]. The p values for the gene overlaps were determined by Fisher’s exact test
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Molecular Autism

ISSN: 2040-2392