Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism

Table 4 NGSEA to identify novel signals in different groups of DNVs (italics: p < 0.05)

	AutDB	Recur	MAGI1	MAGI2	MAGI3	DAWN1	DAWN2	DAWN3	DAWN4
LoFs	0.838	0.07	0.225	0.326	0.224	0.187	0.52	0.502	0.748
Mis-D2	0.762	0.135	0.026	0.347	0.371	0.083	0.274	0.353	0.055
High-5HT_Func	0.734	0.467	0.178	0.759	0.83	0.027	0.335	0.376	0.244
High-5HT_LoFs	0.925	0.234	0.746	0.713	0.637	0.039	0.653	0.82	0.755
Normal-5HT_LoFs	0.481	0.046	0.139	0.147	0.104	0.33	0.801	0.233	0.506
High-5HT_Mis-D2	0.552	0.512	0.098	0.637	0.748	0.04	0.187	0.235	0.137
Normal-5HT_Mis-D2	0.612	0.1	0.031	0.249	0.25	0.174	0.207	0.329	0.035

ISSN: 2040-2392