Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism

Table 3 GSEA of DNVs in High-5HT and Normal-5HT groups with network modules implicated in ASD (italics: p < 0.05)

	MAGI1 (80)	MAGI2 (24)	MAGI3 (91)	DAWN1 (19)	DAWN2 (20)	DAWN3 (58)	DAWN4 (113)
LoFs (16)	0 (1.000)	0 (1.000)	0 (1.000)	0 (1.000)	0 (1.000)	0 (1.000)	3 (8.921e−05)
Mis-Ds2 (56)	1 (0.199)	0 (1.000)	0 (1.000)	1 (0.051)	0 (1.000)	2 (0.011)	0 (1.000)
High-5HT_LoFs (5)	0 (1.000)	0 (1.000)	0 (1.000)	0 (1.000)	0 (1.000)	0 (1.000)	0 (1.000)
High-5HT_Mis-D2(10)	0 (1.000)	0 (1.000)	0 (1.000)	0 (1.000)	0 (1.000)	0 (1.000)	0 (1.000)
Normal-5HT_LoFs (8)	0 (1.000)	0 (1.000)	0 (1.000)	0 (1.000)	0 (1.000)	0 (1.000)	3 (9.216e−06)
Normal-5HT_Mis-D2 (38)	1 (0.140)	0 (1.000)	0 (1.000)	1 (0.035)	0 (1.000)	2 (5.280e−03)	0 (1.000)

ISSN: 2040-2392