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Table 3 GSEA of DNVs in High-5HT and Normal-5HT groups with network modules implicated in ASD (italics: p < 0.05)

From: Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism

  MAGI1 (80) MAGI2 (24) MAGI3 (91) DAWN1 (19) DAWN2 (20) DAWN3 (58) DAWN4 (113)
LoFs (16) 0 (1.000) 0 (1.000) 0 (1.000) 0 (1.000) 0 (1.000) 0 (1.000) 3 (8.921e−05)
Mis-Ds2 (56) 1 (0.199) 0 (1.000) 0 (1.000) 1 (0.051) 0 (1.000) 2 (0.011) 0 (1.000)
High-5HT_LoFs (5) 0 (1.000) 0 (1.000) 0 (1.000) 0 (1.000) 0 (1.000) 0 (1.000) 0 (1.000)
High-5HT_Mis-D2(10) 0 (1.000) 0 (1.000) 0 (1.000) 0 (1.000) 0 (1.000) 0 (1.000) 0 (1.000)
Normal-5HT_LoFs (8) 0 (1.000) 0 (1.000) 0 (1.000) 0 (1.000) 0 (1.000) 0 (1.000) 3 (9.216e−06)
Normal-5HT_Mis-D2 (38) 1 (0.140) 0 (1.000) 0 (1.000) 1 (0.035) 0 (1.000) 2 (5.280e−03) 0 (1.000)