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Fig. 5 | Molecular Autism

Fig. 5

From: Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation

Fig. 5

Cytokine levels in maternal blood and fetal brain 4 h post poly(I:C) exposure. a Poly(I:C) led to a marked increase in the maternal levels of all pro-inflammatory cytokines measured (all ***P < 0.001). VitD co-administration had no effect on MIA-induced maternal pro-inflammatory cytokine production. b Poly(I:C) also led to a significant increase in fetal brain pro-inflammatory cytokines, as supported by the main effect of MIA for IL-1β and IL-6 (***P < 0.001) and TNF-α (*P < 0.05). Again, VitD co-administration did not affect basal or MIA-induced elevations of pro-inflammatory cytokines. All values are mean ± SEM, (n = 6) for CON/VEH, POL/VEH, and POL/VITD groups and (n = 4) for the CON/VITD group

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