|
CHD8+/−
|
Log2FC
|
Padj
|
Log2FC_11
|
FDR
|
Log2FC_31
|
FDR
|
|---|
|
DLX6-AS1
|
5.34
|
3.85E-86
|
4.72
|
1.70E-75
|
4.61
|
7.03E-37
|
|
ARMCX1
|
−2.48
|
4.47E-34
|
NS
|
NS
|
NS
|
NS
|
|
DLX1
|
3.84
|
5.97E-32
|
2.14
|
1.38E-11
|
1.35
|
8.69E-03
|
|
FZD8
|
2.21
|
1.17E-26
|
1.19
|
2.35E-04
|
NS
|
NS
|
|
CPNE6
|
3.55
|
1.47E-24
|
NS
|
NS
|
NS
|
NS
|
|
PAX6
|
2.03
|
2.05E-22
|
NS
|
NS
|
1.29
|
2.23E-04
|
|
SLC1A3
|
1.61
|
2.05E-22
|
1.13
|
9.21E-06
|
NS
|
NS
|
|
EOMES
|
3.10
|
9.04E-22
|
2.96
|
1.85E-17
|
2.79
|
1.17E-06
|
|
MPPED1
|
2.92
|
3.31E-21
|
1.57
|
4.50E-05
|
1.41
|
7.29E-03
|
|
COL25A1
|
2.67
|
4.42E-21
|
NS
|
NS
|
NS
|
NS
|
|
SCGN
|
3.22
|
9.46E-20
|
2.15
|
1.25E-06
|
1.37
|
1.57E-02
|
|
STK17B
|
2.08
|
9.46E-20
|
NS
|
NS
|
NS
|
NS
|
|
LIX1
|
2.14
|
8.70E-19
|
NS
|
NS
|
0.83
|
2.53E-02
|
|
BCL11B
|
1.63
|
7.21E-18
|
0.95
|
4.85E-02
|
2.16
|
2.36E-12
|
|
SHISA2
|
2.14
|
2.29E-17
|
1.41
|
1.58E-06
|
NS
|
NS
|
- Top 15 DEGs in CHD8
+/− are shown in left columns with fold change (FC) and p value adjusted for genome-wide significance (padj). The right columns show the FC and false discovery rate (FDR) values for the same genes, derived from the Mariani et al. study [42]. Log2FC_11 is from day 11 cerebral organoids, while log2FC_31 is from day 31 organoids. Note that DLX6-AS1 was the top DEG in day 11 organoids and the 6th top DEG in day 31 organoids
