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Fig. 3 | Molecular Autism

Fig. 3

From: CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells

Fig. 3

Validation of selected DEGs by qPCR. The RNA samples used in the RNA-seq were used for this analysis. Samples were analyzed in triplicate as described in “Methods” section and Additional file 1: Supplemental methods. Significant differences between control and KO are denoted by an asterisk (*). The p values derived by Student’s t test were as follows: SOX2, 0.047; TCF4, 0.004; HMGA2, 0.00005; PAX6, 0.02; RELN, 0.02; CNTNAP2, 0.04; DLX6-AS1, 0.0001; MEG3, 0.00002

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Molecular Autism

ISSN: 2040-2392