Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: an MRS study

Table 4 Correlation analyses for the autism spectrum disorder group (a p value of <0.025 served as the criterion of significance)

	AQ	EQ	WURS-k	BDI	IQ	Age
Anterior cingulate cortex (n = 24)
GSH	0.077	−0.193	0.287	−0.006	−0.549	−0.567
GSH	0.721	0.366	0.174	0.978	0.005	0.004
Cre	0.183	−0.373	−0.103	−0.082	−0.329	−0.310
Cre	0.393	0.072	0.632	0.702	0.117	0.140
t-Cho	0.286	−0.268	0.063	0.010	−0.106	−0.195
t-Cho	0.175	0.206	0.770	0.964	0.622	0.360
Glx	0.301	−0.394	0.104	−0.019	−0.370	−0.346
Glx	0.152	0.057	0.628	0.931	0.075	0.098
NAA	0.363	−0.399	−0.007	−0.102	−0.297	−0.310
NAA	0.081	0.053	0.974	0.634	0.159	0.140
mI	−0.011	−0.040	−0.013	−0.057	−0.289	−0.339
mI	0.959	0.853	0.952	0.793	0.171	0.105
Dorsolateral prefrontal cortex (n = 24)
GSH	−0.014	−0.058	0.126	0.154	−0.020	−0.166
GSH	0.950	0.790	0.556	0.471	0.927	0.438
Cre	0.042	−0.176	−0.287	−0.283	−0.136	−0.115
Cre	0.847	0.410	0.173	0.180	0.527	0.593
t-Cho	−0.226	0.443	−0.010	−0.027	0.434	0.097
t-Cho	0.289	0.030	0.964	0.901	0.034	0.653
Glx	−0.079	0.162	0.312	−0.179	−0.454	−0.730
Glx	0.713	0.450	0.138	0.402	0.026	0.000
NAA	−0.038	−0.297	0.183	0.033	−0.341	−0.391
NAA	0.861	0.159	0.391	0.880	0.103	0.059
mI	−0.205	0.310	0.004	−0.349	0.005	0.035
mI	0.336	0.141	0.987	0.094	0.982	0.870

Presented are the Pearson correlation coefficients (above) and p values (below)
Significant results are depicted in italics
AQ autism quotient, EQ empathy quotient, WURS Wender Utah Rating scale, BDI Beck Depression Inventory score, IQ intelligence quotient, GSH glutathione, Cre creatine, t-Cho phosphorylcholine + glycerylphosphorylcholine, Glx glutamate + glutamine, NAA N-acetylaspartate, mI myo-inositol (for references, see text)

ISSN: 2040-2392