Skip to main content

Table 3 Neurometabolic results for both analyzed regions (in mM)

From: Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: an MRS study

  Dorsal anterior cingulate cortex MANCOVA without covariates (Wilks’ lambda test p = 0.429) MANCOVA with covariatesa (Wilks’ lambda test p = 0.564) Dorsolateral prefrontal cortex MANCOVA without covariates (Wilks’ lambda test p = 0.288) MANCOVA with covariatesa (Wilks’ lambda test p = 0.262)
  ASD (n = 24) Controls (n = 18)    ASD (n = 24) Controls (n = 18)   
GSH 1.7939 1.9810 p = 0.076 p = 0.147 1.6017 1.6247 p = 0.706 p = 0.655
0.37068 0.26364 0.18921 0.19985
Cre 7.4948 7.9657 p = 0.048 p = 0.082 6.9109 6.6330 p = 0.013 p = 0.020
0.91646 0.39453 0.33509 0.35355
t-Cho 1.8900 1.9926 p = 0.213 p = 0.200 1.8507 1.8289 p = 0.757 p = 0.984
0.27320 0.24132 0.18029 0.27268
Glx 11.7396 12.5834 p = 0.142 p = 0.272 9.4585 9.2360 p = 0.396 p = 0.094
2.14178 1.21151 0.97482 0.58407
NAA 8.1840 8.8939 p = 0.168 p = 0.319 8.8931 8.7972 p = 0.661 p = 0.423
1.82291 1.29632 0.75962 0.59745
mI 5.8211 6.3095 p = 0.018 p = 0.036 5.0549 4.9064 p = 0.344 p = 0.456
0.73532 0.46517 0.50464 0.48836
  1. ASD autism spectrum disorder, MANCOVA multivariate analysis of covariance, p p value to test for differences between groups, GSH glutathione, Cre creatine, t-Cho phosphorylcholine + glycerylphosphorylcholine, Glx glutamate + glutamine, NAA N-acetylaspartate, mI, myo-inositol
  2. aAge, intelligence quotient, and nicotine consumption