|
Androgensa
|
Subject sex
|
Outcomes
|
|---|
| | |
12-month AOSI
|
36-month SRS
|
|---|
| | |
Beta
|
95% CI
|
P
|
P
b
|
Beta
|
95% CI
|
P
|
P
b
|
|---|
|
ln(T)
|
Female (n = 62)
|
0.20
|
(−0.13,0.53)
|
0.22
|
0.95
|
−0.05
|
(−0.31,0.20)
|
0.67
|
0.85
|
| |
Male (n = 75)
|
0.22
|
(−0.13,0.57)
|
0.22
| |
0.14
|
(−0.19,0.46)
|
0.41
| |
|
ln(A4)
|
Female (n = 62)
|
0.11
|
(−0.35,0.57)
|
0.64
|
0.90
|
−0.19
|
(−0.54,0.15)
|
0.27
|
0.89
|
| |
Male (n = 75)
|
0.05
|
(−0.37,0.47)
|
0.81
| |
−0.17
|
(−0.55,0.21)
|
0.38
| |
|
ln(DHEA)
|
Female (n = 62)
|
0.1
|
(−0.18,0.39)
|
0.48
|
0.74
|
−0.04
|
(−0.26,0.17)
|
0.70
|
0.84
|
| |
Male (n = 75)
|
0.02
|
(−0.31,0.36)
|
0.88
| |
−0.01
|
(−0.31,0.32)
|
0.97
| |
-
ln natural log transformed
-
aRobust regression models of loge-transformed testosterone (T), androstenedione (A4), and dehydroepiandrostenedione (DHEA) with total loge (AOSI + 1) and loge (SRS raw) adjusted for gestational age and maternal age. Outcome measures are 12-month Autism Observation Scales for Infants (AOSI) total score and 36-month Social Responsiveness Scale (SRS) total raw score
-
bInteraction P value comes from a model including both subject sexes including covariates, hormone variable, and subject sex hormone interaction
