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Table 3 Summary of gene expression profiling by RT-qPCR

From: Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders

Gene Fold change p values
Cortex
  SCZ ASD HC vs. SCZ HC vs. ASD ASD vs. SCZ
CLDN-1 0.7 2.3 ns ns ns
CLDN-3 2.7 3.0 <0.05 <0.05 ns
CLDN-5 0.5 5.1 ns <0.0001 <0.0001
CLDN-12 0.5 7.7 ns <0.01 <0.001
IBA-1 0.2 1.2 <0.01 ns <0.01
IL-1b 0.4 1.5 ns ns <0.01
IL-6 0.3 1.9 ns ns <0.01
IL-8 0.2 1.1 <0.01 ns <0.01
IL-10 0.5 3.9 ns ns ns
MMP-9 0.9 4.5 ns <0.001 <0.001
MMP-2 0.4 4.9 ns <0.05 <0.001
MSFD2A 0.6 1.5 ns ns ns
OCLN 1.2 1.4 ns ns ns
tPA 0.2 1.7 <0.001 ns <0.01
TRIC 1.3 1.8 ns <0.001 <0.01
TSPO 0.7 1.7 ns <0.05 <0.001
VE-Cad 0.8 1.3 ns ns ns
Cerebellum
CLDN-1 1.3 1.8 ns ns ns
CLDN-3 0.6 1.2 ns ns ns
CLDN-5 1.3 3.6 ns 0.01 <0.05
CLDN-12 1.5 3.7 ns <0.05 ns
IBA-1 1.0 1.2 ns ns ns
IL-1b 2.3 1.0 0.01 ns <0.05
IL-6 1.1 0.3 ns ns ns
IL-8 1.8 0.9 ns ns ns
IL-10 1.3 0.9 ns ns ns
MMP-9 1.0 1.9 ns ns ns
MMP-2 0.7 2.8 ns ns ns
OCLN 1.2 1.5 ns ns ns
tPA 1.2 1.5 ns ns ns
TRIC 0.6 0.9 ns ns ns
TSPO 1.3 1.8 ns <0.05 ns
VE-Cad 1.4 1.3 ns ns ns
Duodenum (biopsies)
CLDN-1 N/A 1.7 N/A ns N/A
CLDN-2 N/A 2.3 N/A ns N/A
CLDN-10 N/A 4.0 N/A ns N/A
CLDN-15 N/A 1.6 N/A ns N/A
OCLN N/A 1.2 N/A ns N/A
TRIC N/A 1.6 N/A ns N/A
  1. Gene expression levels are presented as fold change vs. HC (=1) using the formula 2(−ΔΔCt). Statistical difference among groups is calculated by the one-way ANOVA (Kruskal–Wallis H test). Differences between two groups are calculated by the Mann–Whitney unpaired t test. All data with p < 0.05 were considered significant
  2. ns non-significant, N/A not applicable