Table 3 Summary of gene expression profiling by RT-qPCR
From: Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders
Gene | Fold change | p values | |||
|---|---|---|---|---|---|
Cortex | |||||
SCZ | ASD | HC vs. SCZ | HC vs. ASD | ASD vs. SCZ | |
CLDN-1 | 0.7 | 2.3 | ns | ns | ns |
CLDN-3 | 2.7 | 3.0 | <0.05 | <0.05 | ns |
CLDN-5 | 0.5 | 5.1 | ns | <0.0001 | <0.0001 |
CLDN-12 | 0.5 | 7.7 | ns | <0.01 | <0.001 |
IBA-1 | 0.2 | 1.2 | <0.01 | ns | <0.01 |
IL-1b | 0.4 | 1.5 | ns | ns | <0.01 |
IL-6 | 0.3 | 1.9 | ns | ns | <0.01 |
IL-8 | 0.2 | 1.1 | <0.01 | ns | <0.01 |
IL-10 | 0.5 | 3.9 | ns | ns | ns |
MMP-9 | 0.9 | 4.5 | ns | <0.001 | <0.001 |
MMP-2 | 0.4 | 4.9 | ns | <0.05 | <0.001 |
MSFD2A | 0.6 | 1.5 | ns | ns | ns |
OCLN | 1.2 | 1.4 | ns | ns | ns |
tPA | 0.2 | 1.7 | <0.001 | ns | <0.01 |
TRIC | 1.3 | 1.8 | ns | <0.001 | <0.01 |
TSPO | 0.7 | 1.7 | ns | <0.05 | <0.001 |
VE-Cad | 0.8 | 1.3 | ns | ns | ns |
Cerebellum | |||||
CLDN-1 | 1.3 | 1.8 | ns | ns | ns |
CLDN-3 | 0.6 | 1.2 | ns | ns | ns |
CLDN-5 | 1.3 | 3.6 | ns | 0.01 | <0.05 |
CLDN-12 | 1.5 | 3.7 | ns | <0.05 | ns |
IBA-1 | 1.0 | 1.2 | ns | ns | ns |
IL-1b | 2.3 | 1.0 | 0.01 | ns | <0.05 |
IL-6 | 1.1 | 0.3 | ns | ns | ns |
IL-8 | 1.8 | 0.9 | ns | ns | ns |
IL-10 | 1.3 | 0.9 | ns | ns | ns |
MMP-9 | 1.0 | 1.9 | ns | ns | ns |
MMP-2 | 0.7 | 2.8 | ns | ns | ns |
OCLN | 1.2 | 1.5 | ns | ns | ns |
tPA | 1.2 | 1.5 | ns | ns | ns |
TRIC | 0.6 | 0.9 | ns | ns | ns |
TSPO | 1.3 | 1.8 | ns | <0.05 | ns |
VE-Cad | 1.4 | 1.3 | ns | ns | ns |
Duodenum (biopsies) | |||||
CLDN-1 | N/A | 1.7 | N/A | ns | N/A |
CLDN-2 | N/A | 2.3 | N/A | ns | N/A |
CLDN-10 | N/A | 4.0 | N/A | ns | N/A |
CLDN-15 | N/A | 1.6 | N/A | ns | N/A |
OCLN | N/A | 1.2 | N/A | ns | N/A |
TRIC | N/A | 1.6 | N/A | ns | N/A |