From: Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders
Cortex and CBL | |||||||
MBC # | Age | Race | Sex | Diagnosis | PMI | Cause of death | Additional clinical information |
585 | 42 | AA | M | SCZ | 16 | Pulmonary embolism | Tox (at death): doxepin |
612 | 45 | W | M | SCZ | 24 | Suicide, doxepin intoxication | N/A |
628 | 59 | W | M | SCZ | 13 | Pulmonary thromboembolia | Tox (at death): ETOH, diphenhydramine |
664 | 53 | W | M | SCZ | 11 | ASCVD | Tox (at death): olanzapine |
705 | 47 | W | M | SCZ | 16 | Deep vein thrombosis | N/A |
737 | 55 | W | M | SCZ | 12 | ASCVD | N/A |
741 | 40 | W | M | SCZ | 14 | Motor vehicle accident | Tox (at death): cocaine |
751 | 28 | W | M | SCZ | 34 | Suicide, GSW to chest | Tox (at death): olanzapine |
783 | 53 | W | M | SCZ | 19 | Manner undetermined | N/A |
831 | 53 | W | M | SCZ | 14 | ASCVD | N/A |
4334 | 11 | H | M | ASD | 27 | Acute hemorrhagic tracheobronchitis | History of epilepsy. Brain edema, acute, mild. Otherwise normal brain |
4999 | 20 | W | M | ASD | 14 | Cardiac arrythmia | PDD, autism, and severe mental retardation. Naltrexone |
5027 | 37 | AA | M | ASD | 26 | Obstruction of bowel due to adhesion | Risperdal and Luvox |
5115 | 46 | W | M | ASD | 29 | Complications of pseudomyxoma peritonei | Adult brain with moderate atherosclerosis |
5144 | 7 | W | M | ASD | 3 | Cancer, complication of | Rhabdomyosarcoma |
5176 | 22 | AA | M | ASD | 18 | Subdural hemorrhage | Risperdal |
5308 | 4 | W | M | ASD | 21 | Skull fractures | Struck by a car. Multifocal subarachnoid hemorrhage |
5403 | 16 | W | M | ASD | 35 | Cardiac arrhythmia | Developmental delays. GI evaluations |
1464 | 42 | W | M | Control | 19 | Pulmonary embolism | Chest and abdominal pain, pale, and diaphoretic |
1829 | 25 | W | M | Control | 21 | Electrocution | N/A |
1831 | 44 | W | M | Control | 17 | CO2 inhalation complicating ASCVD | History of hypertension. Complained of headaches |
1936 | 46 | W | M | Control | 13 | ASCVD | History of HBP. Had been experiencing chest pain |
5024 | 56 | W | M | Control | 10 | ASCVD; diabetes mellitus | Smoker, no drinking of ETOH. History of prescription drug abuse. On insulin, metformin, oxycodone, Levaquin, and Lyrica |
5185 | 21 | W | M | Control | 26 | Car accident | Drink ETOH prior to death |
5189 | 40 | W | M | Control | 14 | Cardiac arrhythmia complicated by drowning | Severe stomach pains, chest palpitations, and nausea |
5276 | 22 | W | M | Control | 18 | Heroin intoxication | Asthma and drug abuse; smoker |
5237 | 52 | W | M | Control | 13 | HASCVD | ETOH and cocaine abuse. Clean for 30 days and not feeling well |
5349 | 24 | W | M | Control | 16 | Combined drug intoxication | Drug use |
5553 | 54 | W | M | Control | 17 | Hypertensive atherosclerosis heart disease | History of HTN and daily ETOH intake |
5615 | 50 | W | M | Control | 19 | N/A | N/A |
4337 | 8 | AA | M | Control | 16 | Blunt force neck injury. Car accident | Asthma. Brain petechiae, fresh |
4670 | 4 | W | M | Control | 17 | Commotio cordis (struck by a ball in the sternum) | N/A |
5334 | 12 | H | M | Control | 15 | Hanging/suicide | N/A |
Duodenum (biopsies) | |||||||
Study # | Age | Race | Sex | Diagnosis | GI symptoms | Additional clinical information | |
GBA #2 | 8 | W | M | ASD | Non-apparent | Food allergies, GFCF diet, probiotics | |
GBA #3 | 11 | W | M | ASD | GERD, vomiting, bloating | Asperger’s. No milk diet | |
GBA #6 | 19 | W | M | ASD | Regurgitation after each meal, constipation | History of aggressive behaviors | |
GBA #7 | 21 | W | F | ASD | GERD, erosive esophagitis, IBS, severe constipation, occasional diarrhea | GFCF diet | |
GBA #10 | 9 | W | M | ASD | EoE, GERD, constipation, vomiting | Asthma, somewhat loose stools. Dairy-free diet | |
GBA #12 | 6 | AA | M | ASD | Non-apparent | Eats only pureed food | |
GBA #13 | 5 | AA | M | ASD | Severe constipation, GERD, abdominal pain, runny stools | Asthma, food allergies | |
GBA #14 | 3 | W | M | ASD | Chronic constipation | History of obesity, restricted diet (yogurt, milk, juice) | |
GBA #15 | 11 | W | F | ASD | GERD, constipation | Macrocephaly, sleep disorder | |
GBA #16 | 6 | W | M | ASD | Gastroesophageal reflux, constipation | Food and seasonal allergies, asthma | |
GBA #18 | 16 | W | F | ASD | Constipation, abdominal pain, heartburn, regurgitation | Acute mono, weight loss | |
GBA #20 | 6 | AA | F | ASD | GERD with esophagitis, constipation | ADHD, asthma. Vegetarian | |
GBA #5 | 10 | HL | M | HC | Abdominal pain, nausea, vomiting, sometimes diarrhea | Lactose-free diet | |
GBA #8 | 16 | W | F | HC | Constipation, abdominal pain, burping, bloating | GFCG diet, some FODMAP diet | |
GBA #9 | 16 | W | F | HC | Dysphagia, abdominal pain, regurgitation | ||
GBA #11 | 15 | W | F | HC | Abdominal pain, GERD | Seasonal allergies, lactose intolerance, dairy-free and nut-free diet, ADHD, obesity | |
GBA #17 | 21 | W | F | HC | Nausea, vomiting, upset stomach, GERD. Abdominal pain | Previous duodenitis and gastritis, hepatic adenoma | |
GBA #19 | 6.5 | N/A | M | HC | GERD, constipation | Hydronephrosis, nephrocalcinosis, clubfoot, seasonal allergies, asthma | |
GBA #21 | 15 | W | M | HC | Dysphagia, esophagitis | Asthma | |
GBA #23 | 15 | W | M | HC | Abdominal pain, IBS-like constipation | N/A | |
GBA #24 | 4 | W | M | HC | Reflux | History of constipation. Dairy-free diet |