Fig. 2

Comparison of autistic symptom distribution in children with 22q11.2DupS, subgrouped by ASD diagnosis. Percentage of the with 22q11.2DupS sample (Y-axis) that met individual DSM-5 symptom criteria ASD by expert clinician integration of all of data (ADI-R, ADOS, questionnaires, other clinical observations). The X-axis portrays the seven different symptom clusters in DSM-5. Data are portrayed separately for three groupings of 22q11.2DupS: no ASD diagnosis, community ASD diagnosis, and research ASD diagnosis. Those with a community diagnosis include the subset with a research diagnosis. The lower percentages for the sample carrying a community diagnoses might reflect less specific implementation of diagnostic criteria, implementation of older DSM-IV criteria, or improvements in the child’s behavior since the community diagnosis was made. Note: The first three symptoms listed (i.e., difficulties with social-emotional reciprocity, nonverbal communication, and developing relationships) are all required for a DSM-5 diagnosis of ASD; thus, all participants diagnosed with ASD have, by definition, all three of these symptoms. Abbreviations: ADI-R Autism Diagnostic Interview-Revised, ADOS Autism Diagnostic Observation Schedule, ASD autism spectrum disorder