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Table 3 Clinical Global Impression-Improvement scale score, NAC vs. placebo

From: A randomized placebo-controlled pilot study of N-acetylcysteine in youth with autism spectrum disorder

  Groups Test of differences
  NAC Placebo
  n/total % n/total % Chi-squarea
Week 4      0.28
 Response 4/15 26.7 5/14 35.7  
 No response 11/15 73.3 9/14 64.3  
Week 8      0.07
 Response 5/13 38.5 4/12 33.3  
 No response 8/13 61.5 8/12 66.7  
Week 12      0.15
 Response 6/12 50.0 5/11 45.5  
 No response 6/12 50.0 6/11 54.5  
  1. aOne-tailed significance + p < .10; *p < .05. No p values for these chi-squares reached significance at .05 and ranged from .60 to .79
  2. Response = very much improved (1) or much improved (2); no response = minimally improved (3), no change (4), minimally worse (5); no participants scored much worse (6) or very much worse (7)
  3. NAC N-acetylcysteine
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Molecular Autism

ISSN: 2040-2392