| |
NAC (n = 16)
|
Placebo (n = 15)
|
|---|
|
Adverse effects
|
Mild
|
Mod
|
Severe
|
Mild
|
Mod
|
Severe
|
|---|
|
URI
|
9
|
1
|
0
|
5
|
1
|
0
|
|
Headache
|
3
|
0
|
0
|
2
|
1
|
0
|
|
Stomachache
|
2
|
0
|
0
|
2
|
0
|
0
|
|
Fever
|
2
|
1
|
0
|
0
|
0
|
0
|
|
Irritability
|
2
|
0
|
0
|
1
|
0
|
0
|
|
Insomnia
|
2
|
0
|
0
|
0
|
0
|
0
|
|
Otitis media
|
1
|
1
|
0
|
1
|
0
|
0
|
|
Increased enuresis
|
1
|
0
|
0
|
1
|
0
|
0
|
|
Interrupted sleep
|
1
|
0
|
0
|
1
|
0
|
0
|
|
Localized rash
|
1
|
0
|
0
|
1
|
0
|
0
|
|
Nausea
|
1
|
0
|
0
|
1
|
0
|
0
|
|
Stereotypy
|
0
|
0
|
0
|
2
|
0
|
0
|
- The table only lists adverse effects occurring ≥2 times across the samples
- Placebo group reported one moderate case of the following adverse effects: defiant behavior, hives, itchy skin, and threats to hurt self
- Placebo group reported one mild case of the following adverse effects: accidental injury (arm), constipation, diarrhea, dry mouth, emotional outburst, encopresis, increased hyperactivity, self-injurious behavior (skin picking), sinus infection, skin infection, sore throat, urinary tract infection, and weight gain
- NAC group reported one mild case of the following adverse effects: aggression, appetite increase, behavior worse, change in speech, early morning awakening, edema, medical or surgical procedure, swollen neck/lymph nodes, and tic
-
NAC N-acetylcysteine, Mod moderate, URI upper respiratory infection
