Skip to main content

Table 2 Frequency of adverse effects

From: A randomized placebo-controlled pilot study of N-acetylcysteine in youth with autism spectrum disorder

 

NAC (n = 16)

Placebo (n = 15)

Adverse effects

Mild

Mod

Severe

Mild

Mod

Severe

URI

9

1

0

5

1

0

Headache

3

0

0

2

1

0

Stomachache

2

0

0

2

0

0

Fever

2

1

0

0

0

0

Irritability

2

0

0

1

0

0

Insomnia

2

0

0

0

0

0

Otitis media

1

1

0

1

0

0

Increased enuresis

1

0

0

1

0

0

Interrupted sleep

1

0

0

1

0

0

Localized rash

1

0

0

1

0

0

Nausea

1

0

0

1

0

0

Stereotypy

0

0

0

2

0

0

  1. The table only lists adverse effects occurring ≥2 times across the samples
  2. Placebo group reported one moderate case of the following adverse effects: defiant behavior, hives, itchy skin, and threats to hurt self
  3. Placebo group reported one mild case of the following adverse effects: accidental injury (arm), constipation, diarrhea, dry mouth, emotional outburst, encopresis, increased hyperactivity, self-injurious behavior (skin picking), sinus infection, skin infection, sore throat, urinary tract infection, and weight gain
  4. NAC group reported one mild case of the following adverse effects: aggression, appetite increase, behavior worse, change in speech, early morning awakening, edema, medical or surgical procedure, swollen neck/lymph nodes, and tic
  5. NAC N-acetylcysteine, Mod moderate, URI upper respiratory infection