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Table 2 Frequency of adverse effects

From: A randomized placebo-controlled pilot study of N-acetylcysteine in youth with autism spectrum disorder

  NAC (n = 16) Placebo (n = 15)
Adverse effects Mild Mod Severe Mild Mod Severe
URI 9 1 0 5 1 0
Headache 3 0 0 2 1 0
Stomachache 2 0 0 2 0 0
Fever 2 1 0 0 0 0
Irritability 2 0 0 1 0 0
Insomnia 2 0 0 0 0 0
Otitis media 1 1 0 1 0 0
Increased enuresis 1 0 0 1 0 0
Interrupted sleep 1 0 0 1 0 0
Localized rash 1 0 0 1 0 0
Nausea 1 0 0 1 0 0
Stereotypy 0 0 0 2 0 0
  1. The table only lists adverse effects occurring ≥2 times across the samples
  2. Placebo group reported one moderate case of the following adverse effects: defiant behavior, hives, itchy skin, and threats to hurt self
  3. Placebo group reported one mild case of the following adverse effects: accidental injury (arm), constipation, diarrhea, dry mouth, emotional outburst, encopresis, increased hyperactivity, self-injurious behavior (skin picking), sinus infection, skin infection, sore throat, urinary tract infection, and weight gain
  4. NAC group reported one mild case of the following adverse effects: aggression, appetite increase, behavior worse, change in speech, early morning awakening, edema, medical or surgical procedure, swollen neck/lymph nodes, and tic
  5. NAC N-acetylcysteine, Mod moderate, URI upper respiratory infection