From: Synaptic vesicle dynamic changes in a model of fragile X
HC | CB | |||||
---|---|---|---|---|---|---|
Protein name | Ratio Fmr1 KO/WT | p value | q value | Ratio Fmr1 KO/WT | p value | q value |
Signal transduction | ||||||
Plasma membrane calcium-transporting ATPase 2 (AT2B2)a, b, e | 1.11 | 0.6403 | 0.8270 | 1.16 | 0.2314 | 0.2953 |
Sodium potassium transporting ATPase alpha 1 (AT1A1)a | 0.99 | 0.8710 | 0.9194 | 1.32 | 2.60*10 −11 | 3.20*10 −10 |
Sodium potassium transporting ATPase alpha 3 (AT1A3)a | 0.74 | 0.0076 | 0.0480 | 1.66 | 2.50*10 −07 | 1.03*10 −06 |
Sodium potassium transporting ATPase beta 1 (AT1B1)a | 1.01 | 0.9524 | 0.9524 | 1.27 | 2.63*10 −10 | 2.43*10 −09 |
Sodium potassium transporting ATPase beta 2 (AT1B2)a | 1.21 | 0.0509 | 0.1874 | 1.19 | 0.0122 | 0.0215 |
Synaptic vesicle glycoprotein 2A (SV2A)b, d | 1.02 | 0.6529 | 0.8270 | 1.20 | 0.0002 | 0.0005 |
Synaptic vesicle glycoprotein 2B (SV2B)b | 0.86 | 0.1754 | 0.3715 | 0.92 | 0.5270 | 0.5909 |
Neuronal development | ||||||
Brain acid soluble protein 1 (BASP1)c | 0.77 | <2.60*10 −11 | <2.60*10 −11 | 1.75 | 8.15*10 −07 | 3.02*10 −06 |
Neuromodulin (NEUM)a | 0.88 | 0.0751 | 0.1874 | 0.77 | 0.0071 | 0.0146 |
Neurotransmission: GABA/glutamate-related proteins | ||||||
BTB POZ domain containing protein KCTD12 (KCD12)a | 0.73 | 0.38*10 −05 | 0.0004 | 1.17 | 0.0098 | 0.0192 |
Glutamate receptor 1 (GRIA1)b, d | 0.83 | 0.0789 | 0.1874 | 1.77 | 1.35*10 −07 | 6.24*10 −07 |
Glutamate receptor 3 (GRIA3)b, d | 0.87 | 0.1760 | 0.3715 | 1.34 | 0.0160 | 0.0269 |
Succinate semialdehyde dehydrogenase (SSDH)a | 1.06 | 0.3880 | 0.5897 | 0.93 | 0.3833 | 0.4432 |
Vesicular glutamate transporter 1 (VGLU1)a | 1.02 | 0.8017 | 0.8934 | 1.23 | 0.0222 | 0.0342 |
Excitatory amino acid transporter 1 (EAA1)a | 1.14 | 0.3178 | 0.5251 | 1.13 | 0.3431 | 0.4095 |
Glutamate decarboxylase 1 (DCE1)b | 0.94 | 0.6107 | 0.8270 | 0.95 | 0.7279 | 0.7782 |
Glutamate decarboxylase 2 (DCE2)b, d | 0.81 | 0.3422 | 0.5419 | 1.27 | 0.2416 | 0.2979 |
FMRP-related proteins | ||||||
Cytoplasmic FMR1-interacting protein 1 (CYFP1)b, d | 0.65 | 0.0205 | 0.0973 | 1.45 | 0.0437 | 0.0621 |
Cytoplasmic FMR1-interacting protein 2 (CYFP2)b | 1.04 | 0.7761 | 0.8934 | 1.41 | 0.0217 | 0.0342 |
Fragile X mental retardation syndrome-related 2 (FXR2)c | 1.04 | 0.7108 | 0.8713 | 1.26 | 0.0070 | 0.0146 |