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Table 1 Protein changes validated using SRM-MS in the mouse brain synaptosome fractions

From: Synaptic vesicle dynamic changes in a model of fragile X

 

HC

CB

Protein name

Ratio Fmr1 KO/WT

p value

q value

Ratio Fmr1 KO/WT

p value

q value

Signal transduction

      

 Plasma membrane calcium-transporting ATPase 2 (AT2B2)a, b, e

1.11

0.6403

0.8270

1.16

0.2314

0.2953

 Sodium potassium transporting ATPase alpha 1 (AT1A1)a

0.99

0.8710

0.9194

1.32

2.60*10 −11

3.20*10 −10

 Sodium potassium transporting ATPase alpha 3 (AT1A3)a

0.74

0.0076

0.0480

1.66

2.50*10 −07

1.03*10 −06

 Sodium potassium transporting ATPase beta 1 (AT1B1)a

1.01

0.9524

0.9524

1.27

2.63*10 −10

2.43*10 −09

 Sodium potassium transporting ATPase beta 2 (AT1B2)a

1.21

0.0509

0.1874

1.19

0.0122

0.0215

 Synaptic vesicle glycoprotein 2A (SV2A)b, d

1.02

0.6529

0.8270

1.20

0.0002

0.0005

 Synaptic vesicle glycoprotein 2B (SV2B)b

0.86

0.1754

0.3715

0.92

0.5270

0.5909

Neuronal development

      

 Brain acid soluble protein 1 (BASP1)c

0.77

<2.60*10 −11

<2.60*10 −11

1.75

8.15*10 −07

3.02*10 −06

 Neuromodulin (NEUM)a

0.88

0.0751

0.1874

0.77

0.0071

0.0146

Neurotransmission: GABA/glutamate-related proteins

      

 BTB POZ domain containing protein KCTD12 (KCD12)a

0.73

0.38*10 −05

0.0004

1.17

0.0098

0.0192

 Glutamate receptor 1 (GRIA1)b, d

0.83

0.0789

0.1874

1.77

1.35*10 −07

6.24*10 −07

 Glutamate receptor 3 (GRIA3)b, d

0.87

0.1760

0.3715

1.34

0.0160

0.0269

 Succinate semialdehyde dehydrogenase (SSDH)a

1.06

0.3880

0.5897

0.93

0.3833

0.4432

 Vesicular glutamate transporter 1 (VGLU1)a

1.02

0.8017

0.8934

1.23

0.0222

0.0342

 Excitatory amino acid transporter 1 (EAA1)a

1.14

0.3178

0.5251

1.13

0.3431

0.4095

 Glutamate decarboxylase 1 (DCE1)b

0.94

0.6107

0.8270

0.95

0.7279

0.7782

 Glutamate decarboxylase 2 (DCE2)b, d

0.81

0.3422

0.5419

1.27

0.2416

0.2979

FMRP-related proteins

      

 Cytoplasmic FMR1-interacting protein 1 (CYFP1)b, d

0.65

0.0205

0.0973

1.45

0.0437

0.0621

 Cytoplasmic FMR1-interacting protein 2 (CYFP2)b

1.04

0.7761

0.8934

1.41

0.0217

0.0342

 Fragile X mental retardation syndrome-related 2 (FXR2)c

1.04

0.7108

0.8713

1.26

0.0070

0.0146

  1. * this is the multiply sign
  2. The table includes Uniprot ID, ratios (calculated based on average), P values and adjusted P values (Q). Significant proteins are indicated in italics
  3. aProteins indicated in LC-MSE brain study
  4. bProteins indicated in LC-MSE synaptosome study
  5. cProteins associated with FMRP in literature
  6. dIsoforms of indicated proteins in B or S
  7. eFamily member of proteins indicated in B or S