Skip to main content
Fig. 7 | Molecular Autism

Fig. 7

From: Brinp1 −/− mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

Fig. 7

Increased PV+ interneuron cell density in the adult Brinp1 knock-out neocortex and hippocampus. a Representative coronal section showing parvalbumin (PV)-positive interneurons in the neocortex and medial hippocampus of WT and Brinp1 −/− mice. b An increase in number of PV-positive cells in bins 3 and 5, corresponding with layers IV–VI of the somatosensory neocortex of Brinp1 −/− mice, F(6) = 21.602, p = 0.004, repeat measures two-way ANOVA. c An increase in total numbers of PV-positive cells was observed in the somatosensory neocortex of Brinp1 −/− mice, t(6) = 4.684, p = 0.0034. d PV-positive interneurons in the hippocampus: i) an increase in total numbers of PV-positive cells in the hippocampus of Brinp1 −/− mice t(6) = 2.497, p = 0.0467. ii) A near significant difference was observed for the CA1 region, p = 0.087, whilst no significant differences were observed for CA2, CA3 or dentate gyrus regions. N = 4 mice per genotype

Back to article page

Molecular Autism

ISSN: 2040-2392