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Fig. 6 | Molecular Autism

Fig. 6

From: Brinp1 −/− mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

Fig. 6

Brinp1 knock-out mice show normal PPI and impaired short-term memory. a. Brinp1 −/− mice showed i) normal startle response; female: t(10) = 0.288, p = 0.779, male: t(10) = 1.045, p = 0.321, unpaired Student’s t test, and ii) and no significant effect of genotype on pre-pulse inhibition (PPI), female: F(1,10) = 0.695, p = 0.424, male: F(1,10) = 0.003, p = 0.958, repeat measures two-way ANOVA. N = 6 female, 6 male mice per genotype. b Y-maze: Results from two cohorts tested indicate that Brinp1−/− mice did not display an increase in time spent exploring the novel arm, in comparison to WT controls. Analysis by repeat measures two-way ANOVA revealed a significant interaction effect for genotype × arm; female: F(2,40) = 3.829, p = 0.030, male: F(2,40) = 3.737, p = 0.033. N = 11 female, 11 male mice per genotype. Data presented as the mean ± SE. c Brinp1 −/− mice showed no impairment in learning the location of a hidden platform in the Morris water maze: i) no significant main effect of genotype on time locating the platform; female: F(1,9) = 0.530, p = 0.819, male: F(1,9) = 0.160, p = 692. N = 5 female, 5 male mice per genotype. Data presented as the mean ± SE. ii) Male Brinp1 −/− mice showed an improvement in locating the platform on day 1, as a decrease in time to find the platform, t(38) = 2.549, p = 0.0173, unpaired Student’s t tests. Data presented as the mean ± SD except where otherwise stated. *p < 0.05, **p < 0.0.1, ***p < 0.001, ****p < 0.0001

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