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Fig. 4 | Molecular Autism

Fig. 4

From: Overexpression of Homer1a in the basal and lateral amygdala impairs fear conditioning and induces an autism-like social impairment

Fig. 4

Viral mediated overexpression of Homer1a in the BLA impaired social interaction but did not influence innate fear and locomotory behavior: Animals overexpressing Homer1a exhibit anxiety levels similar to GFP animals in the open field as indicated by (a) a similar number of center entries and (b) similar center time as compared to GFP animals. c The mean total distance traveled was not different between the groups (GFP = 8, Homer1a = 9). Animals overexpressing Homer1a exhibit reduced social interaction compared to GFP animals as indicated by (d) reduced social interaction time without affecting (e) mean distance traveled in the social interaction apparatus. Bars represent the mean ± standard error of the mean (SEM) (*p < 0.05)

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