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Table 2 Global brain volumes of ASD subjects and controls in the entire dataset, in male and female subgroups, and in DD and no-DD male (m) and female (f) subsets

From: The effect of gender on the neuroanatomy of children with autism spectrum disorders: a support vector machine case-control study

Variable (ml) Subject group, mean ± std ANOVA
  ASD (n = 76) C (n = 76) ASD vs. C
F p
GM (ml) 662 ± 67 629 ± 80 7.39 0.007
WM (ml) 424 ± 47 400 ± 55 8.84 0.003
CSF (ml) 225 ± 25 218 ± 34 2.41 0.123
TIV 1310 ± 130 1250 ± 160 7.18 0.008
  ASDm (n = 38) ASDf (n = 38) Cm (n = 38) Cf (n = 38) ASDm vs. Cm ASDf vs. Cf
F p F p
GM (ml) 699 ± 62 625 ± 48 664 ± 83 594 ± 60 4.25 0.043 5.90 0.018
WM (ml) 449 ± 43 400 ± 38 422 ± 56 376 ± 44 5.38 0.023 5.93 0.017
CSF (ml) 238 ± 25 212 ± 17 232 ± 38 203 ± 19 0.52 0.470 5.08 0.027
TIV (ml) 1390 ± 120 1240 ± 100 1320 ± 170 1170 ± 120 3.90 0.052 6.13 0.016
  ASD-DDm (n = 19) ASD-noDDm (n = 19) ASD-DDf (n = 19) ASD-noDDf (n = 19) C-DDm (n = 19) C-no-DDm (n = 19) C-DDf (n = 19) C-no-DDf (n = 19) ASD-DDm vs. C-DDm ASD-noDDm vs. C-noDDm ASD-DDf vs. C-DDf ASD-noDDf vs. C-noDDf
F p F p F p F p
GM (ml) 702 ± 85 696 ± 65 616 ± 59 633 ± 35 661 ± 85 668 ± 83 584 ± 53 605 ± 66 2.98 0.09 1.34 0.255 3.21 0.081 2.73 0.107
WM (ml) 453 ± 44 445 ± 43 393 ± 44 406 ± 31 424 ± 62 421 ± 51 369 ± 41 384 ± 47 2.72 0.108 2.55 0.119 3.04 0.090 2.90 0.097
CSF (ml) 238 ± 31 238 ± 28 211 ± 20 213 ± 13 228 ± 31 236 ± 44 200 ± 16 206 ± 22 1.13 0.294 0.01 0.906 3.54 0.068 1.65 0.207
TIV (ml) 1390 ± 210 1380 ± 130 1220 ± 120 1250 ± 70 1310 ± 170 1330 ± 170 1150 ± 110 1200 ± 130 2.71 0.109 1.24 0.272 3.37 0.075 2.78 0.104
  1. Abbreviations: ASD autism spectrum disorder, C controls, ASDm ASD males, Cm control males, ASDf ASD females, Cf control females, ASD-DDm ASD males with developmental delay, C-DDm control males with developmental delay, ASD-noDDm ASD males without developmental delay, C-noDDm control males without developmental delay, ASD-DDf ASD females with developmental delay, C-DDf control females with developmental delay, ASD-noDDf ASD females without developmental delay, C-noDDf control females without developmental delay, GM grey matter, WM white matter, CSF cerebrospinal fluid, TIV total intracranial volume, std standard deviation