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Fig. 3 | Molecular Autism

Fig. 3

From: Profiling olfactory stem cells from living patients identifies miRNAs relevant for autism pathophysiology

Fig. 3

Expression of miR-146a and miR-221 in the brain. a ISH of miR-146a and miR-221 in the adult mouse brain. Typical coronal slices showed elevated miR-146a in the hippocampal CA1 and dentate gyrus (DG), the amygdala nuclei (amyg), and the entorhinal cortex (ctx). b Hybridization of scramble or miR-146a and miR-221 was performed onto mice at different developmental from embryonic (E11 and E16) and postnatal (P5 and P30) stages. Arrows indicate hippocampal formation or territories at the different age, allowing appreciation of the specific labeling of different cellular layers in the postnatal brains. c Neuronal expression of both miRNAs was confirmed by combining miR-ISH with fluorescent labeling of neuronal (NeuN) and glial (GFAP) cells in the CA1 region

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