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Table 3 Baseline, Week 11, and change in primary and secondary outcome measures

From: A randomized, placebo-controlled trial of d-cycloserine for the enhancement of social skills training in autism spectrum disorders

Clinical Outcome DCS (n=34) Placebo (n=33)   
Mean (SD) Mean (SD)
  Baseline 11-week Change Baseline 11-week Change Difference in Change Scores (95% CI) P-value
Primary outcome         
Social Responsiveness Scale (SRS) Parent Raw Scores
 Social awareness 12.82 (3.43) 12.15 (2.73) -0.76 (2.60) 13.82 (3.59) 12.94 (2.67) -1.00 (3.12) 0.24 (-1.19 to 1.67) .74
 Social cognition 19.18 (5.37) 17.21 (6.01) -1.94 (4.41) 20.88 (4.34) 18.06 (4.24) -2.68 (3.74) 0.74 (-1.31 to 2.79) .47
 Social communication 34.94 (8.65) 30.00 (8.55) -4.91 (6.49) 37.97 (7.84) 32.03 (7.71) -6.19 (8.40) 1.28 (-2.45 to 5.02) .49
 Social motivation 16.06 (5.84) 13.18 (5.01) -2.76 (3.95) 16.33 (5.34) 13.39 (5.17) -3.06 (4.40) 0.31 (-1.78 to 2.40) .54
 Autistic mannerisms 19.44 (6.10) 16.42 (6.03) -2.82 (5.24) 21.42 (6.27) 17.65 (5.36) -4.10 (6.38) 1.28 (-1.63 to 4.19) .38
SRS Parent Total Score 102.35 (25.09) 88.67 (22.74) -13.39 (16.81) 110.33 (20.43) 94.00 (19.31) -17.00 (21.33) 3.61 (-5.96 to 13.17) .45
Secondary outcomes         
VABS-II raw scores         
 Communication 152.56 (17.05) 156.47 (17.85) 3.63 (8.26) 147.06 (22.18) 154.58 (21.93) 6.77 (11.15) -3.15 (-8.08 to 1.79) .21
 Daily living skills 231.62 (26.08) 239.56 (26.99) 7.06 (14.72) 229.67 (35.43) 239.29 (35.76) 8.45 (16.82) -1.39 (-9.35 to 6.57) .73
 Socialization 113.26 (24.98) 126.53 (27.54) 12.34 (20.00) 103.97 (22.14) 117.35 (27.94) 12.10 (22.28) 0.25 (-10.41 to 10.91) .96
 Motor skills 141.21 (7.21) 143.59 (5.42) 2.22 (5.70) 141.27 (9.50) 142.19 (9.59) 0.19 (3.81) 2.03 (-0.41 to 4.46) .10
 Maladaptive behavior 16.65 (6.87) 15.88 (7.12) -0.59 (5.92) 18.55 (7.42) 16.42 (5.59) -2.03 (5.91) 1.44 (-1.54 to 4.42) .34
 Total 655.29 (59.88) 682.03 (64.28) 24.66 (37.56) 640.52 (78.65) 669.84 (83.74) 25.48 (41.11) -0.83 (-20.66 to 19.00) .93
 ABC parent score         
  Irritability 11.06 (8.05) 9.12 (6.63) -1.55 (6.11) 12.67 (8.96) 11.06 (7.42) -1.23 (6.09) -0.32 (-3.37 to 2.73) .83
  Social Withdrawal 10.29 (8.30) 8.06 (7.61) -2.39 (4.71) 10.39 (8.33) 8.81 (6.41) -1.71 (7.04) -0.68 (-3.71 to 2.34) .65
  Stereotypy 4.94 (4.21) 4.64 (4.89) -0.33 (2.79) 4.64 (4.32) 4.32 (3.75) -0.45 (4.60) 0.12 (-1.81 to 2.04) .90
  Hyperactivity 18.82 (11.26) 17.30 (12.23) -1.55 (7.37) 19.00 (9.18) 16.87 (9.49) -2.03 (9.39) 0.49 (-3.72 to 4.69) .82
  Inappropriate speech 3.91 (3.04) 3.24 (2.26) -0.73 (2.59) 4.36 (2.85) 4.68 (3.29) 0.35 (2.67) -1.08 (-2.40 to 0.23) .10
 TSSA parent 53.74 (8.61) 57.84 (9.11) 3.88 (3.49) 48.79 (8.91) 54.34 (10.37) 5.83 (9.70) -1.95 (-6.87 to 2.97) .43