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Table 3 Baseline, Week 11, and change in primary and secondary outcome measures

From: A randomized, placebo-controlled trial of d-cycloserine for the enhancement of social skills training in autism spectrum disorders

Clinical Outcome

DCS (n=34)

Placebo (n=33)

  

Mean (SD)

Mean (SD)

 

Baseline

11-week

Change

Baseline

11-week

Change

Difference in Change Scores (95% CI)

P-value

Primary outcome

        

Social Responsiveness Scale (SRS) Parent Raw Scores

 Social awareness

12.82 (3.43)

12.15 (2.73)

-0.76 (2.60)

13.82 (3.59)

12.94 (2.67)

-1.00 (3.12)

0.24 (-1.19 to 1.67)

.74

 Social cognition

19.18 (5.37)

17.21 (6.01)

-1.94 (4.41)

20.88 (4.34)

18.06 (4.24)

-2.68 (3.74)

0.74 (-1.31 to 2.79)

.47

 Social communication

34.94 (8.65)

30.00 (8.55)

-4.91 (6.49)

37.97 (7.84)

32.03 (7.71)

-6.19 (8.40)

1.28 (-2.45 to 5.02)

.49

 Social motivation

16.06 (5.84)

13.18 (5.01)

-2.76 (3.95)

16.33 (5.34)

13.39 (5.17)

-3.06 (4.40)

0.31 (-1.78 to 2.40)

.54

 Autistic mannerisms

19.44 (6.10)

16.42 (6.03)

-2.82 (5.24)

21.42 (6.27)

17.65 (5.36)

-4.10 (6.38)

1.28 (-1.63 to 4.19)

.38

SRS Parent Total Score

102.35 (25.09)

88.67 (22.74)

-13.39 (16.81)

110.33 (20.43)

94.00 (19.31)

-17.00 (21.33)

3.61 (-5.96 to 13.17)

.45

Secondary outcomes

        

VABS-II raw scores

        

 Communication

152.56 (17.05)

156.47 (17.85)

3.63 (8.26)

147.06 (22.18)

154.58 (21.93)

6.77 (11.15)

-3.15 (-8.08 to 1.79)

.21

 Daily living skills

231.62 (26.08)

239.56 (26.99)

7.06 (14.72)

229.67 (35.43)

239.29 (35.76)

8.45 (16.82)

-1.39 (-9.35 to 6.57)

.73

 Socialization

113.26 (24.98)

126.53 (27.54)

12.34 (20.00)

103.97 (22.14)

117.35 (27.94)

12.10 (22.28)

0.25 (-10.41 to 10.91)

.96

 Motor skills

141.21 (7.21)

143.59 (5.42)

2.22 (5.70)

141.27 (9.50)

142.19 (9.59)

0.19 (3.81)

2.03 (-0.41 to 4.46)

.10

 Maladaptive behavior

16.65 (6.87)

15.88 (7.12)

-0.59 (5.92)

18.55 (7.42)

16.42 (5.59)

-2.03 (5.91)

1.44 (-1.54 to 4.42)

.34

 Total

655.29 (59.88)

682.03 (64.28)

24.66 (37.56)

640.52 (78.65)

669.84 (83.74)

25.48 (41.11)

-0.83 (-20.66 to 19.00)

.93

 ABC parent score

        

  Irritability

11.06 (8.05)

9.12 (6.63)

-1.55 (6.11)

12.67 (8.96)

11.06 (7.42)

-1.23 (6.09)

-0.32 (-3.37 to 2.73)

.83

  Social Withdrawal

10.29 (8.30)

8.06 (7.61)

-2.39 (4.71)

10.39 (8.33)

8.81 (6.41)

-1.71 (7.04)

-0.68 (-3.71 to 2.34)

.65

  Stereotypy

4.94 (4.21)

4.64 (4.89)

-0.33 (2.79)

4.64 (4.32)

4.32 (3.75)

-0.45 (4.60)

0.12 (-1.81 to 2.04)

.90

  Hyperactivity

18.82 (11.26)

17.30 (12.23)

-1.55 (7.37)

19.00 (9.18)

16.87 (9.49)

-2.03 (9.39)

0.49 (-3.72 to 4.69)

.82

  Inappropriate speech

3.91 (3.04)

3.24 (2.26)

-0.73 (2.59)

4.36 (2.85)

4.68 (3.29)

0.35 (2.67)

-1.08 (-2.40 to 0.23)

.10

 TSSA parent

53.74 (8.61)

57.84 (9.11)

3.88 (3.49)

48.79 (8.91)

54.34 (10.37)

5.83 (9.70)

-1.95 (-6.87 to 2.97)

.43