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Table 3 Summary of findings

From: Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures

  Differentially expressed genes in Fmr1KO vs WT (disease genes)
Culture Brain
Hippocampus Cortex Hippocampus Cortex
Number of differentially expressed genes 2648 3372 726 866
Distance between KO and WT clusters on PCA (PC1/PC2) 3.73/0.7 3.31/3.20 0.99/0.6 0.39/0.32
Pathway enrichment Neuronal processes Immune processes
Human development Early (H0 cluster) Early (C0 cluster) Later (H1 cluster) Later (C2 cluster)
Up-regulated Up-regulated Down- and up- regulated Up-regulated
SFARI human genes Significantly enriched in down-regulated genes Significantly enriched in down-regulated genes Not significant Not significant
MGI mouse genes associated with behavioral/neurological phenotype Significantly enriched in down-regulated genes Significantly enriched in down-regulated genes Not significant Not significant
FMRP targets Significantly enriched in down-regulated genes Significantly enriched in down- and up- regulated genes Not significant Not significant