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Table 1 Enriched pathways in differentially expressed genes in brain and primary cultures of Fmr1KO mice

From: Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures

KEGG pathway (ENTREZ ID as input) p value No. of genes Fold enrichment
Hippocampal culture    
mmu04910:Insulin signaling pathway 0.001 35 1.748
mmu03040:Spliceosome 0.001 32 1.801
mmu00900:Terpenoid backbone biosynthesis 0.002 8 3.796
mmu04720:Long-term potentiation 0.003 20 2.013
mmu04120:Ubiquitin mediated proteolysis 0.008 32 1.586
mmu04360:Axon guidance 0.009 31 1.584
mmu03010:Ribosome 0.011 22 1.740
mmu05211:Renal cell carcinoma 0.013 19 1.803
mmu04540:Gap junction 0.017 21 1.701
mmu04722:Neurotrophin signaling pathway 0.017 29 1.541
mmu00230:Purine metabolism 0.022 33 1.461
mmu00650:Butanoate metabolism 0.029 11 2.088
mmu04012:ErbB signaling pathway 0.031 21 1.603
mmu05215:Prostate cancer 0.038 21 1.567
mmu03018:RNA degradation 0.039 15 1.748
mmu03020:RNA polymerase 0.040 9 2.214
 mmu00790:Folate biosynthesis 0.070 5 3.019
 mmu04914:Progesterone-mediated oocyte maturation 0.078 19 1.485
 mmu04150:mTOR signaling pathway 0.080 13 1.661
 mmu00240:Pyrimidine metabolism 0.088 20 1.444
 mmu05220:Chronic myeloid leukemia 0.088 17 1.506
Cortical culture    
mmu04622:RIG-I-like receptor signaling pathway 0.001 23 2.027
mmu03040:Spliceosome 0.001 37 1.686
mmu04722:Neurotrophin signaling pathway 0.006 36 1.548
mmu04144:Endocytosis 0.012 48 1.395
mmu04660:T cell receptor signaling pathway 0.013 31 1.529
mmu04010:MAPK signaling pathway 0.016 63 1.308
mmu04120:Ubiquitin mediated proteolysis 0.018 36 1.444
mmu05220:Chronic myeloid leukemia 0.029 22 1.577
 mmu04720:Long-term potentiation 0.052 19 1.548
 mmu00534:Heparan sulfate biosynthesis 0.062 9 2.016
 mmu03450:Non-homologous end-joining 0.076 6 2.481
 mmu04062:Chemokine signaling pathway 0.080 41 1.267
 mmu05210:Colorectal cancer 0.096 22 1.391
Hippocampus in situ    
mmu04144:Endocytosis 0.013 14 2.133
mmu04060:Cytokine-cytokine receptor interaction 0.013 16 1.986
mmu05322:Systemic lupus erythematosus 0.014 8 3.088
mmu04514:Cell adhesion molecules (CAMs) 0.017 11 2.348
mmu05320:Autoimmune thyroid disease 0.028 6 3.451
 mmu05330:Allograft rejection 0.051 5 3.523
 mmu04672:Intestinal immune network for IgA production 0.082 5 2.998
 mmu04610:Complement and coagulation cascades 0.099 6 2.415
Cortex in situ    
mmu00590:Arachidonic acid metabolism 0.016 9 2.727
mmu04210:Apoptosis 0.029 9 2.439
 mmu04640:Hematopoietic cell lineage 0.059 8 2.275
 mmu04060:Cytokine-cytokine receptor interaction 0.064 16 1.623
 mmu00601:Glycosphingolipid biosynthesis 0.083 4 3.838
  1. Italics highlight pathways with p values <0.05