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Fig. 5 | Molecular Autism

Fig. 5

From: A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice

Fig. 5

NL3R451C mice display heightened aggression which is rescued by risperidone. a Vehicle-treated NL3R451C mice showed an increased risk of attacking compared to WT mice, which was reversed with risperidone. In the WT mice, the risk of an attack was unchanged following risperidone treatment. The NL3R451C mice attacked b more often , c for longer and d displayed more tail rattles compared to the WT mice. All measures of aggression were also reduced by risperidone. e Risperidone increased the duration of agonistic social interactions in the NL3R451C mice compared to the vehicle-treated mice. Values for ae are an average of four tests, and data in be are displayed as box plots with medians plus the 25th and 75th percentiles. Whiskers represent the minimum and maximum values. Asterisks represent a statistically significant difference between indicated groups. *p < 0.05

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