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Table 1 Expression changes of genes associated with brain volume or head size from GWAS

From: CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment

Ref. Trait SNP Associated gene Coordinate CHD8-binding in NPCs CHD8 +/− NPC CHD8 +/− neuron
log2(FC) q value log2(FC) q value
[68] Hippocampal volume rs7294919 TESC chr12:117476728-117537284 N 0.42 0.89 −2.78 0.0020
[68] Total brain volume rs10494373 DDR2 chr1:162601163-162750237 N 4.12 1.68E-31 5.70 2.82E-13
[68] Intracranial volume rs10784502 HMGA2 chr12:66217911-66360075 Y 1.00 3.57E-06 2.97 6.67E-08
[69] Infant head circumference rs1042725
[69] Infant head circumference rs7980687 SBNO1 chr12:123773656-123849390 Y −0.15 0.61 −0.45 0.023
[69] Infant head circumference rs11655470 MAPT chr17:43971748-44105700 N 0.61 0.40 −1.82 0.070
CRHR1 chr17:43699267-43913194 N 0.15 0.90 −0.13 0.86
[67] Intracranial volume rs17689882 CRHR1 chr17:43699267-43913194 N 0.15 0.90 −0.13 0.86
[67] Putamen volume rs945270 KTN1 chr14:56025790-56168244 Y −0.22 0.67 −0.09 0.80
[67] Putamen volume rs683250 DLG2 chr11:83166055-85338966 Y 0.66 0.69 −0.059 0.96
[67] Caudate volume rs1318862 FAT3 chr11:92085262-92629618 N −0.92 2.45E-05 −1.27 4.98E-06
[67] Putamen volume rs6087771 BCL2L1 chr20:30252255-30311792 Y 0.10 0.89 −0.67 0.029
[67] Hippocampal volume rs61921502 MSRB3 chr12:65672423-65882024 N 0.33 0.79 2.63 8.69E-24
[67] Putamen volume rs62097986 DCC chr18:49866542-51057784 Y 0.72 0.31 −0.18 0.1
  1. Significant fold changes are set in italics