CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment

Table 1 Expression changes of genes associated with brain volume or head size from GWAS

Ref.	Trait	SNP	Associated gene	Coordinate	CHD8-binding in NPCs	CHD8 ^+/− NPC		CHD8 ^+/− neuron
Ref.	Trait	SNP	Associated gene	Coordinate	CHD8-binding in NPCs	log2(FC)	q value	log2(FC)	q value
[68]	Hippocampal volume	rs7294919	TESC	chr12:117476728-117537284	N	0.42	0.89	−2.78	0.0020
[68]	Total brain volume	rs10494373	DDR2	chr1:162601163-162750237	N	4.12	1.68E-31	5.70	2.82E-13
[68]	Intracranial volume	rs10784502	HMGA2	chr12:66217911-66360075	Y	1.00	3.57E-06	2.97	6.67E-08
[69]	Infant head circumference	rs1042725	HMGA2	chr12:66217911-66360075	Y	1.00	3.57E-06	2.97	6.67E-08
[69]	Infant head circumference	rs7980687	SBNO1	chr12:123773656-123849390	Y	−0.15	0.61	−0.45	0.023
[69]	Infant head circumference	rs11655470	MAPT	chr17:43971748-44105700	N	0.61	0.40	−1.82	0.070
[69]	Infant head circumference	rs11655470	CRHR1	chr17:43699267-43913194	N	0.15	0.90	−0.13	0.86
[67]	Intracranial volume	rs17689882	CRHR1	chr17:43699267-43913194	N	0.15	0.90	−0.13	0.86
[67]	Putamen volume	rs945270	KTN1	chr14:56025790-56168244	Y	−0.22	0.67	−0.09	0.80
[67]	Putamen volume	rs683250	DLG2	chr11:83166055-85338966	Y	0.66	0.69	−0.059	0.96
[67]	Caudate volume	rs1318862	FAT3	chr11:92085262-92629618	N	−0.92	2.45E-05	−1.27	4.98E-06
[67]	Putamen volume	rs6087771	BCL2L1	chr20:30252255-30311792	Y	0.10	0.89	−0.67	0.029
[67]	Hippocampal volume	rs61921502	MSRB3	chr12:65672423-65882024	N	0.33	0.79	2.63	8.69E-24
[67]	Putamen volume	rs62097986	DCC	chr18:49866542-51057784	Y	0.72	0.31	−0.18	0.1

ISSN: 2040-2392