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Fig. 7 | Molecular Autism

Fig. 7

From: CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment

Fig. 7

Enriched GO terms shared among five lists of DEGs from four studies. DEGs were from CHD8 +/− NPC (current data), NPC knockdown (NPC_KD) [25], NSC knockdown by two independent shRNAs (NSC_KD_shC, NSC_KD_shG) [26], or SK-N-SH knockdown (SK-N-SH_KD) [27]. Nodes represent common GO terms (names not displayed) and grey edges between them depict the degrees of gene overlap between terms. GO Terms enriched in 3, 4, and 5 DEG lists are colored blue, orange, and red, respectively. Individual GO terms with a similar gene composition were clustered into functional groups by ClueGO and drawn together as circles, with the functions labeled in red font. Square boxes represent each of the five DEG lists and colored edges connect enriched GO terms in individual studies. This visualization was created using ClueGO plugin in the Cytoscape

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