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Table 1 Subject demographic information

From: NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder

Pair ID Age Gender RIN a PMI (hours) b Toxicology Assays Tissue
Control donors
1 AN14757 24 M 7.8 21.33 No drugs reported LCMc, qPCRd BA24, BA10
2 AN07176 21 M 8 29.91 No drugs reported LCM, qPCR BA24, BA10
3 AN07444 17 M 7.5 30.75 Sertraline LCM, qPCR BA24
4 5408 6 M 7 16 No drugs reported LCM, qPCR BA24, BA10
5 4848 16 M 7.6 15 No drugs reported LCM, qPCR BA24, BA10
6 5342 22 M 8.1 14 No drugs reported LCM, qPCR BA24, BA10
7 5079 33 M 7.3 16 Ethanol LCM, qPCR BA24, BA10
8 M3231M 37 M 7.4 24 No drugs reported LCM, qPCR BA24, BA10
9 4590 20 M 7.6 19 No drugs reported LCM, qPCR BA10
Mean ± SEM (BA24 donors) 22.0±3.4   7.59±0.13 20.9±2.4    
Mean ± SEM (BA10 donors) 22.4±3.4   7.60±0.13 19.4±1.9    
ASD donors
1 AN04166 24 M 8.1 18.51 No drugs reported LCM, qPCR BA24, BA10
2 AN03935 20 M 8.6 28 No drugs reported LCM, qPCR BA24, BA10
3 AN02987 15 M 6.5 30.83 No drugs reported LCM, qPCR BA24
4 5144 7 M 8.0 3 No drugs reported LCM, qPCR BA24, BA10
5 5302 16 M 6.6 20 Risperidone, fluvoxamine, clonidine, insulin LCM, qPCR BA24, BA10
6 5176 22 M 7.1 18 Risperidone LCM, qPCR BA24, BA10
7 5297 33 M 7.1 50 Quetiapine, fluoxetine, valproate, ziprasidone LCM, qPCR BA24, BA10
8 5027 37 M 7.7 26 Risperidone, fluvoxamine LCM, qPCR BA24, BA10
9 4999 20 M 7.0 14 No drugs reported LCM, qPCR BA10
Mean ± SEM (BA24 donors) 21.6±3.4   7.46±0.27 24.3±4.8    
Mean ± SEM (BA10 donors) 22.2±3.3   7.53±0.24 23.4±5.4    
P value e (BA 24) 0.94   0.68 0.53    
P value e (BA10) 0.98   0.79 0.60    
  1. aRNA integrity number (index of RNA quality); bpostmortem interval; cendpoint PCR analysis of reversed transcribed RNA isolated from cells collected by laser capture microdissection; dquantitative polymerase chain reaction of reverse transcribed RNA isolated from punch-dissected tissues; eresults of a two-tailed independent t-test comparing control and ASD groups. BA24, Brodmann area 24; BA10, Brodmann area 10; LCM, laser capture microdissection.