|
Pair
|
ID
|
Age
|
Gender
|
RIN
a
|
PMI (hours)
b
|
Toxicology
|
Assays
|
Tissue
|
|---|
|
Control donors
|
|
1
|
AN14757
|
24
|
M
|
7.8
|
21.33
|
No drugs reported
|
LCMc, qPCRd
|
BA24, BA10
|
|
2
|
AN07176
|
21
|
M
|
8
|
29.91
|
No drugs reported
|
LCM, qPCR
|
BA24, BA10
|
|
3
|
AN07444
|
17
|
M
|
7.5
|
30.75
|
Sertraline
|
LCM, qPCR
|
BA24
|
|
4
|
5408
|
6
|
M
|
7
|
16
|
No drugs reported
|
LCM, qPCR
|
BA24, BA10
|
|
5
|
4848
|
16
|
M
|
7.6
|
15
|
No drugs reported
|
LCM, qPCR
|
BA24, BA10
|
|
6
|
5342
|
22
|
M
|
8.1
|
14
|
No drugs reported
|
LCM, qPCR
|
BA24, BA10
|
|
7
|
5079
|
33
|
M
|
7.3
|
16
|
Ethanol
|
LCM, qPCR
|
BA24, BA10
|
|
8
|
M3231M
|
37
|
M
|
7.4
|
24
|
No drugs reported
|
LCM, qPCR
|
BA24, BA10
|
|
9
|
4590
|
20
|
M
|
7.6
|
19
|
No drugs reported
|
LCM, qPCR
|
BA10
|
|
Mean ± SEM (BA24 donors)
|
22.0±3.4
| |
7.59±0.13
|
20.9±2.4
| | | |
|
Mean ± SEM (BA10 donors)
|
22.4±3.4
| |
7.60±0.13
|
19.4±1.9
| | | |
|
ASD donors
|
|
1
|
AN04166
|
24
|
M
|
8.1
|
18.51
|
No drugs reported
|
LCM, qPCR
|
BA24, BA10
|
|
2
|
AN03935
|
20
|
M
|
8.6
|
28
|
No drugs reported
|
LCM, qPCR
|
BA24, BA10
|
|
3
|
AN02987
|
15
|
M
|
6.5
|
30.83
|
No drugs reported
|
LCM, qPCR
|
BA24
|
|
4
|
5144
|
7
|
M
|
8.0
|
3
|
No drugs reported
|
LCM, qPCR
|
BA24, BA10
|
|
5
|
5302
|
16
|
M
|
6.6
|
20
|
Risperidone, fluvoxamine, clonidine, insulin
|
LCM, qPCR
|
BA24, BA10
|
|
6
|
5176
|
22
|
M
|
7.1
|
18
|
Risperidone
|
LCM, qPCR
|
BA24, BA10
|
|
7
|
5297
|
33
|
M
|
7.1
|
50
|
Quetiapine, fluoxetine, valproate, ziprasidone
|
LCM, qPCR
|
BA24, BA10
|
|
8
|
5027
|
37
|
M
|
7.7
|
26
|
Risperidone, fluvoxamine
|
LCM, qPCR
|
BA24, BA10
|
|
9
|
4999
|
20
|
M
|
7.0
|
14
|
No drugs reported
|
LCM, qPCR
|
BA10
|
|
Mean ± SEM (BA24 donors)
|
21.6±3.4
| |
7.46±0.27
|
24.3±4.8
| | | |
|
Mean ± SEM (BA10 donors)
|
22.2±3.3
| |
7.53±0.24
|
23.4±5.4
| | | |
|
P value
e
(BA 24)
|
0.94
| |
0.68
|
0.53
| | | |
|
P value
e
(BA10)
|
0.98
| |
0.79
|
0.60
| | | |
-
aRNA integrity number (index of RNA quality); bpostmortem interval; cendpoint PCR analysis of reversed transcribed RNA isolated from cells collected by laser capture microdissection; dquantitative polymerase chain reaction of reverse transcribed RNA isolated from punch-dissected tissues; eresults of a two-tailed independent t-test comparing control and ASD groups. BA24, Brodmann area 24; BA10, Brodmann area 10; LCM, laser capture microdissection.
