Region | BA | Hemisphere | MNI coordinates | T value | Cluster-level P value a | Cluster size (voxels) | |||
---|---|---|---|---|---|---|---|---|---|
 |  |  | x | y | z | ||||
Model 1: ASD > TDC | |||||||||
  Thalamus cluster | Medial dorsal nucleus of thalamus |  | L | −1 | −12 | 19 | 4.71 | 0.014 | 563 |
 | Medial dorsal nucleus of thalamus |  |  | 0 | −6 | 9 | 4.09 |  |  |
 | Lateral dorsal nucleus of thalamus |  | R | 11 | −21 | 15 | 3.71 |  |  |
  Right orbital frontal cluster | Inferior frontal gyrus | 47 | R | 3 | 8 | −24 | 4.68 | 0.002 | 761 |
 |  |  | R | 27 | 15 | −23 | 4.37 |  |  |
 |  |  | R | 30 | 27 | −27 | 4.17 |  |  |
Model 1: ASD < TDC | |||||||||
  Temporo-parieto-occipital junction cluster | Angular/middle occipital gyrus | 39 | L | −40 | −75 | 30 | 3.81 | 0.058b | 430 |
 | Precuneus/middle occipital gyrus | 19 | L | −27 | −84 | 40 | 3.75 |  |  |
 | Precuneus/middle occipital gyrus | 19 | L | −36 | −75 | 42 | 3.51 |  |  |
Model 2: ASD > TDC | |||||||||
  Thalamus cluster | Medial dorsal nucleus of thalamus |  | L | −1 | −12 | 19 | 4.79 | 0.003 | 697 |
 | Lateral dorsal nucleus of thalamus | … | R | 11 | −21 | 15 | 3.93 |  |  |
 |  |  | … | 0 | 3 | 18 | 3.43 |  |  |
  Right inferior orbital frontal cluster | Inferior frontal gyrus | 47 | R | 3 | 8 | −24 | 4.63 | 0.009 | 605 |
 | Inferior frontal gyrus | 47 | R | 27 | 15 | −23 | 4.35 |  |  |
 | Inferior frontal gyrus | 47 | R | 30 | 27 | −27 | 4.10 |  |  |
Model 2: ASD by age > TDC by age | |||||||||
  Cuneus cluster | Cuneus | 18 |  | 0 | −90 | 16 | 5.51 | <0.001 | 2,813 |
 | Cuneus | 19 | R | 26 | −85 | 34 | 4.34 |  |  |
 | Cuneus | 17 | R | 2 | −82 | 12 | 4.31 |  |  |
  Anterior prefrontal cluster | Medial frontal gyrus | 10 | L | −6 | 71 | −3 | 5.45 | <0.001 | 4,277 |
 | Superior frontal gyrus | 10 | L | −19 | 71 | −3 | 5.27 |  |  |
 | Middle frontal gyrus | 10 | L | −30 | 51 | −9 | 4.92 |  |  |
Model 2: ASD by age < TDC by age | Â | Â | Â | Â | Â | Â | Â | Â | Â |
  Left cerebellum cluster | Crus I | … | L | −51 | −58 | −30 | 4.52 | <0.001 | 1,666 |
 | Crus I | … | L | −46 | −48 | −32 | 4.39 |  |  |
 | Crus I | … | L | −42 | −42 | −33 | 4.11 |  |  |
  Right caudate cluster | Caudate | … | R | 18 | 3 | 16 | 4.01 | 0.050b | 443 |
 | Caudate | … | R | 18 | 3 | 16 | 3.73 |  |  |
 | Caudate | … | R | 12 | −3 | 22 | 3.72 |  |  |
  Left caudate cluster | Caudate | … | L | −18 | −1 | 24 | 3.57 | 0.042 | 457 |
 | Caudate | … | L | −18 | 11 | 15 | 3.45 |  |  |
 | Caudate | … | L | −15 | 21 | 15 | 3.19 |  |  |
Model 3: Child, ASD > TDC | Â | Â | Â | Â | Â | Â | Â | Â | Â |
  Limbic cluster | Subcallosal gyrus | 34 | L | −12 | 5 | −15 | 3.91 | 0.002 | 732 |
 | Sub-lobar | … | R | 5 | 5 | −12 | 3.90 |  |  |
 | Sub-lobar | … | L | −7 | 2 | −8 | 3.80 |  |  |
Model 3: Child, ASD < TDC | Â | Â | Â | Â | Â | Â | Â | Â | Â |
  Right postcentral cluster | Postcentral gyrus | 3 | R | 41 | −34 | 63 | 4.29 | 0.028 | 495 |
 | Postcentral gyrus | 3 | R | 35 | −25 | 69 | 4.20 |  |  |
 | Postcentral gyrus | 3 | R | 30 | −34 | 64 | 4.06 |  |  |
  Left parieto-occipital junction cluster | Precuneus | 19 | L | −27 | −82 | 39 | 4.19 | 0.016 | 546 |
 | Precuneus | 19 | L | −34 | −82 | 34 | 4.01 |  |  |
 | Middle occipital gyrus | 19 | L | −32 | −91 | 24 | 3.43 |  |  |
Model 3: Adult, ASD > TDC | Â | Â | Â | Â | Â | Â | Â | Â | Â |
  Right dorsal medial prefrontal cluster | Superior frontal gyrus | 9 | R | 12 | 56 | 34 | 5.40 | <0.001 | 1,192 |
 | Superior frontal gyrus | 10 | R | 8 | 51 | 42 | 4.89 |  |  |
 | Superior frontal gyrus | 10 | R | 5 | 66 | 9 | 4.83 |  |  |
  Left anterior/dorsal medial prefrontal cluster | Superior frontal gyrus | 10 | L | −7 | 56 | 1 | 4.75 | 0.005 | 561 |
 | Superior frontal gyrus | 10 | L | −7 | 72 | −3 | 4.74 |  |  |
 | Medial frontal gyrus | 10 | L | −10 | 71 | 6 | 4.24 |  |  |
  Left lateral prefrontal cluster | Middle frontal gyrus | 10 | L | −39 | 51 | −17 | 4.91 | 0.018 | 465 |
 | Superior frontal gyrus | 10 | L | −33 | 59 | −3 | 4.37 |  |  |
 | Superior frontal gyrus | 10 | L | −31 | 51 | −8 | 3.82 |  |  |
  Cuneus cluster | Cuneus | 18 | R | 2 | −84 | 22 | 4.25 | 0.022 | 447 |
 | Cuneus | 18 | … | 0 | −76 | 32 | 4.17 |  |  |
 | Cuneus | 18 | R | 8 | −91 | 14 | 4.11 |  |  |