Model 1: ASD > TDC
|
Thalamus cluster
|
Medial dorsal nucleus of thalamus
| |
L
|
−1
|
−12
|
19
|
4.71
|
0.014
|
563
|
|
Medial dorsal nucleus of thalamus
| | |
0
|
−6
|
9
|
4.09
| | |
|
Lateral dorsal nucleus of thalamus
| |
R
|
11
|
−21
|
15
|
3.71
| | |
Right orbital frontal cluster
|
Inferior frontal gyrus
|
47
|
R
|
3
|
8
|
−24
|
4.68
|
0.002
|
761
|
| | |
R
|
27
|
15
|
−23
|
4.37
| | |
| | |
R
|
30
|
27
|
−27
|
4.17
| | |
Model 1: ASD < TDC
|
Temporo-parieto-occipital junction cluster
|
Angular/middle occipital gyrus
|
39
|
L
|
−40
|
−75
|
30
|
3.81
|
0.058b
|
430
|
|
Precuneus/middle occipital gyrus
|
19
|
L
|
−27
|
−84
|
40
|
3.75
| | |
|
Precuneus/middle occipital gyrus
|
19
|
L
|
−36
|
−75
|
42
|
3.51
| | |
Model 2: ASD > TDC
|
Thalamus cluster
|
Medial dorsal nucleus of thalamus
| |
L
|
−1
|
−12
|
19
|
4.79
|
0.003
|
697
|
|
Lateral dorsal nucleus of thalamus
|
…
|
R
|
11
|
−21
|
15
|
3.93
| | |
| | |
…
|
0
|
3
|
18
|
3.43
| | |
Right inferior orbital frontal cluster
|
Inferior frontal gyrus
|
47
|
R
|
3
|
8
|
−24
|
4.63
|
0.009
|
605
|
|
Inferior frontal gyrus
|
47
|
R
|
27
|
15
|
−23
|
4.35
| | |
|
Inferior frontal gyrus
|
47
|
R
|
30
|
27
|
−27
|
4.10
| | |
Model 2: ASD by age > TDC by age
|
Cuneus cluster
|
Cuneus
|
18
| |
0
|
−90
|
16
|
5.51
|
<0.001
|
2,813
|
|
Cuneus
|
19
|
R
|
26
|
−85
|
34
|
4.34
| | |
|
Cuneus
|
17
|
R
|
2
|
−82
|
12
|
4.31
| | |
Anterior prefrontal cluster
|
Medial frontal gyrus
|
10
|
L
|
−6
|
71
|
−3
|
5.45
|
<0.001
|
4,277
|
|
Superior frontal gyrus
|
10
|
L
|
−19
|
71
|
−3
|
5.27
| | |
|
Middle frontal gyrus
|
10
|
L
|
−30
|
51
|
−9
|
4.92
| | |
Model 2: ASD by age < TDC by age
| | | | | | | | | |
Left cerebellum cluster
|
Crus I
|
…
|
L
|
−51
|
−58
|
−30
|
4.52
|
<0.001
|
1,666
|
|
Crus I
|
…
|
L
|
−46
|
−48
|
−32
|
4.39
| | |
|
Crus I
|
…
|
L
|
−42
|
−42
|
−33
|
4.11
| | |
Right caudate cluster
|
Caudate
|
…
|
R
|
18
|
3
|
16
|
4.01
|
0.050b
|
443
|
|
Caudate
|
…
|
R
|
18
|
3
|
16
|
3.73
| | |
|
Caudate
|
…
|
R
|
12
|
−3
|
22
|
3.72
| | |
Left caudate cluster
|
Caudate
|
…
|
L
|
−18
|
−1
|
24
|
3.57
|
0.042
|
457
|
|
Caudate
|
…
|
L
|
−18
|
11
|
15
|
3.45
| | |
|
Caudate
|
…
|
L
|
−15
|
21
|
15
|
3.19
| | |
Model 3: Child, ASD > TDC
| | | | | | | | | |
Limbic cluster
|
Subcallosal gyrus
|
34
|
L
|
−12
|
5
|
−15
|
3.91
|
0.002
|
732
|
|
Sub-lobar
|
…
|
R
|
5
|
5
|
−12
|
3.90
| | |
|
Sub-lobar
|
…
|
L
|
−7
|
2
|
−8
|
3.80
| | |
Model 3: Child, ASD < TDC
| | | | | | | | | |
Right postcentral cluster
|
Postcentral gyrus
|
3
|
R
|
41
|
−34
|
63
|
4.29
|
0.028
|
495
|
|
Postcentral gyrus
|
3
|
R
|
35
|
−25
|
69
|
4.20
| | |
|
Postcentral gyrus
|
3
|
R
|
30
|
−34
|
64
|
4.06
| | |
Left parieto-occipital junction cluster
|
Precuneus
|
19
|
L
|
−27
|
−82
|
39
|
4.19
|
0.016
|
546
|
|
Precuneus
|
19
|
L
|
−34
|
−82
|
34
|
4.01
| | |
|
Middle occipital gyrus
|
19
|
L
|
−32
|
−91
|
24
|
3.43
| | |
Model 3: Adult, ASD > TDC
| | | | | | | | | |
Right dorsal medial prefrontal cluster
|
Superior frontal gyrus
|
9
|
R
|
12
|
56
|
34
|
5.40
|
<0.001
|
1,192
|
|
Superior frontal gyrus
|
10
|
R
|
8
|
51
|
42
|
4.89
| | |
|
Superior frontal gyrus
|
10
|
R
|
5
|
66
|
9
|
4.83
| | |
Left anterior/dorsal medial prefrontal cluster
|
Superior frontal gyrus
|
10
|
L
|
−7
|
56
|
1
|
4.75
|
0.005
|
561
|
|
Superior frontal gyrus
|
10
|
L
|
−7
|
72
|
−3
|
4.74
| | |
|
Medial frontal gyrus
|
10
|
L
|
−10
|
71
|
6
|
4.24
| | |
Left lateral prefrontal cluster
|
Middle frontal gyrus
|
10
|
L
|
−39
|
51
|
−17
|
4.91
|
0.018
|
465
|
|
Superior frontal gyrus
|
10
|
L
|
−33
|
59
|
−3
|
4.37
| | |
|
Superior frontal gyrus
|
10
|
L
|
−31
|
51
|
−8
|
3.82
| | |
Cuneus cluster
|
Cuneus
|
18
|
R
|
2
|
−84
|
22
|
4.25
|
0.022
|
447
|
|
Cuneus
|
18
|
…
|
0
|
−76
|
32
|
4.17
| | |
|
Cuneus
|
18
|
R
|
8
|
−91
|
14
|
4.11
| | |