Duplication of the Wolf-Hirschhorn region in patient 1. Map of chromosome 4 (1-6,000,000, hg19) showing the rearrangement detected in patient 1 and previously reported overlapping rearrangements. The region commonly deleted in Wolf-Hirschhorn syndrome and the two proposed critical regions (WHSCR1 and WHSCR2) are represented. Horizontal blue lines represent duplications, and red lines indicate deletions. RefSeq genes are indicated at the bottom of the map.