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Figure 3 | Molecular Autism

Figure 3

From: Fmrp targets or not: long, highly brain-expressed genes tend to be implicated in autism and brain disorders

Figure 3

Sets of random genes sampled to match both the length and expression overlap autism candidate genes. (A) Scatterplot of all genes (grey dots) and Fmrp target genes (purple circles) and corresponding contours. (B) Contours of all genes, dark gray, Fmrp target genes (light gray), and a set of genes sampled to match the Fmrp genes (blue). (C) Lists of genes sampled on length and expression overlap with autism risk genes approximately as well as Fmrp target genes. (D) Histogram of the P values resulting from 1,000 Fisher’ exact tests using random gene sets, each sampled to match the Fmrp target’s both on length and expression levels, compared to SFARIdb (top panel) or rDNV genes (bottom panel). Sampled gene sets were often as significant as the true Fmrp target list (red arrow, P < 1.2e − 11, P < 6.1e − 12).

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