Sex differences in cortical projection zone subregions across three MRI time points. Estimated trajectories depicted were estimated for TCV equal to the time 1 average for TD children before the scanner upgrade. (A) The orbitofrontal fiber region is smaller in males with ASD than in TD males but does not differ in females. (B) The anterior frontal fiber region is smaller in females with ASD than in TD females. In males, the opposite pattern is observed; males with ASD are larger than TD males. (C) The superior frontal fiber region is smaller in both males and females with ASD than TD counterparts, though the difference is larger in females.