Recurrence risk for ASD in multiplex families from AGRE by sex and family type. ASD risk to all children born first after the second affected child in each family (N = 456 children from 341 families) is highest for males and in female-containing families. Mosaic plots show the proportion of affected children by (A) sex, (B) family type as FC (female-containing) or MO (male-only), and by (C) sex within each family type. Bar widths are proportional to the number of children or families in each group, which is also noted in the figure. Whiskers note the 95% confidence intervals around each recurrence rate estimate.