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Table 2 Correlation coefficients for RORA and target gene expression in the postmortem frontal cortex of control males

From: Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism

Comparison

CYP19A1 vs. RORA*

A2BP1 vs. RORA

ITPR1 vs. RORA

NLGN1 vs. RORA

Correlation coefficient

0.99

0.83

0.72

0.81

P val (2-tailed)

0.03

0.38

0.49

0.39

R2

0.99

0.69

0.52

0.66

  1. The correlation coefficients between RORA expression and that of several of its target genes were derived from a re-analysis of previously published gene expression data [33]. The two-tailed P values for the correlations and the coefficient of determination (R2) are also shown. Ages of the control male donors were 19, 22, and 28 years. Not shown are the analogous correlation data for male donors with ASD, aged 20, 22, and 30 years.
  2. *With the ASD group, the correlation coefficient, P value, and R2 was identical to that of the male controls for the relationship between RORA and CYP19A1, while the correlation between RORA expression and that of the other three target genes was low (R2 < 0.36).
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Molecular Autism

ISSN: 2040-2392