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Figure 5 | Molecular Autism

Figure 5

From: Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism

Figure 5

Expression ofRoraand several of its transcriptional targets* in the frontal cortex of mice. (A) The scatter plot shows the relative transcript levels of Rora and several of its transcriptional targets (Cyp19a1, A2bp1, Itpr1, Nlgn1) in the frontal cortex of female (F) and male (M) C57BL/6 mice. There are three females and three males per group. (B) Table showing the female-to-male (F/M) expression ratios for each of the genes analyzed and two-tailed P values, t-values, effect sizes, and power for the comparisons of the group means for females and males. Using the means and standard deviations for the analyses, power was calculated for a two-sided t-test with three samples/group for which α was set at 0.05. *The transcriptional targets in mice were inferred based on RORA promoter binding analysis in SH-SY5Y cells [33].

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Molecular Autism

ISSN: 2040-2392