Figure 2

Cerebral synaptosome structural abnormalities were improved by antipurinergic therapy. (A) Fragile X knockout model treated with saline (KO-Saline). Note the increased electron density (dark staining) of the synaptosomal matrix (*) and the hypomorphic (thin) margins of the post-synaptic density (indicated by the arrow). Age 25 weeks, N = 3 per group. Scale bar = 200 nm. (B) Fragile X knockout model treated with suramin (KO-Suramin). Note the normal appearing, electron lucent synaptosomal matrix (*) and the thicker margins of the post-synaptic density (indicated by the arrow). Age 25 weeks, N = 3 per group. Scale bar = 200 nm.