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Figure 1 | Molecular Autism

Figure 1

From: Abnormal lateralization of functional connectivity between language and default mode regions in autism

Figure 1

Lateralized hub locations and abnormally lateralized connections. The left- (red) and right-lateralized (blue) brain regions that participate in the most left- and right-lateralized connections, as determined in a separate sample of 1,011 typically developing subjects, are displayed on rendered brain images. A) Three connections (black lines) are less left-lateralized in the autism group compared to the typically developing group when all 964 subjects are included in the analysis. B) All of the connections with an false discovery rate (FDR)-corrected group difference for at least one of the eight criteria in Table 1 are displayed. The lines between the regions of interest (ROIs) are weighted according to the number of criteria that the connections met FDR-corrected significance. Abbreviations: AI, anterior insula; Bh, Broca homologue; Br, Broca area; DL, dorsolateral prefrontal cortex; DP, inferior dorsolateral prefrontal cortex; FE, frontal eye fields; IP, superior medial intraparietal sulcus; LI, lateral intraparietal sulcus; LP, lateral premotor cortex; l-S, left supplementary motor area; MC, mid cingulate cortex; MI, mid insula; MP, medial prefrontal cortex; MT, middle temporal area; PC, posterior cingulate cortex; PO, parietooccipital cortex; r-S, right supplementary motor area; SF, medial superior frontal cortex; TP, temporoparietal junction; We, Wernicke area.

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