|  |  | General NDPa | Impulsivitya | Learning problemsa | Tics and autisma | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene/SNP | MAF | Genotype | N | A ll | N | B oys | N | G irls | A ll | B oys | G irls | A ll | B oys | G irls | A ll | B oys | G irls |
CDH9/10 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | ||
rs4307059 | 0.37(C) | C/C | 1,149 | 0.128 (0.70) | 538 | 0.235 (0.72) | 611 | 0.034 (0.66) | 0.032 (0.53) | 0.034 (0.53) | 0.030 (0.52) | 0.002 (0.59) | 0.017 (0.62) | -0.010 (0.57) | 0.067 (0.51) | 0.144 (0.51) | -0.002 (0.49) |
 |  | T/C | 3,923 | 0.172 (0.71) | 1,998 | 0.275 (0.73) | 1,925 | 0.064 (0.68) | 0.028 (0.54) | 0.021 (0.55) | 0.034 (0.53) | 0.051 (0.62) | 0.085 (0.65) | 0.016 (0.58) | 0.069 (0.55) | 0.138 (0.58) | -0.003 (0.50) |
 |  | T/T | 3,424 | 0.132 (0.69) | 1,711 | 0.244 (0.71) | 1,713 | 0.019 (0.66) | 0.023 (0.54) | 0.038 (0.55) | 0.009 (0.52) | 0.031 (0.62) | 0.066 (0.65) | -0.004 (0.59) | 0.057 (0.50) | 0.105 (0.53) | 0.009 (0.47) |
P valueb | Â | Â | Â | 0.962 | Â | 0.661 | Â | 0.811 | 0.554 | 0.571 | 0.959 | 0.401 | 0.474 | 0.702 | 0.734 | 0.702 | 0.695 |
Effect size (CI 95%)c | Â | 0.001 (-0.021, 0.022) | Â | 0.007 (-0.024, 0.037) | Â | -0.004 (-0.034, 0.027) | 0.005 (-0.011, 0.021) | 0.006 (-0.016, 0.029) | 0.001 (-0.024, 0.025) | -0.007 (-0.023, 0.009) | -0.008 (-0.028, 0.013) | -0.005 (-0.033, 0.022) | 0.002 (-0.012, 0.017) | 0.004 (-0.017, 0.025) | 0.004 (-0.018, 0.026) | ||
CNTNAP2 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
rs2710102 | 0.48(G) | A/A | 2,316 | 0.121 (0.70) | 1,153 | 0.203 (0.72) | 1,163 | 0.040 (0.68) | 0.004 (0.53) | 0.002 (0.54) | 0.007 (0.51) | 0.050 (0.61) | 0.056 (0.62) | 0.043 (0.60) | 0.057 (0.53) | 0.126 (0.56) | -0.012 (0.49) |
 |  | A/G | 4,242 | 0.158 (0.70) | 2,126 | 0.274 (0.72) | 2,116 | 0.041 (0.65) | 0.030 (0.54) | 0.037 (0.56) | 0.023 (0.53) | 0.033 (0.63) | 0.075 (0.67) | -0.010 (0.58) | 0.069 (0.52) | 0.125 (0.55) | 0.013 (0.49) |
 |  | G/G | 1,924 | 0.164 (0.70) | 966 | 0.268 (0.71) | 958 | 0.059 (0.68) | 0.040 (0.54) | 0.036 (0.55) | 0.043 (0.53) | 0.027 (0.60) | 0.063 (0.63) | -0.008 (0.57) | 0.066 (0.53) | 0.130 (0.56) | 0.001 (0.49) |
P valueb | Â | Â | Â | 0.501 | Â | 0.135 | Â | 0.634 | 0.344 | 0.315 | 0.767 | 0.450 | 0.692 | 0.167 | 0.768 | 0.856 | 0.746 |
Effect size (CI 95%)c | Â | 0.007 (-0.014, 0.029) | Â | 0.025 (-0.008, 0.057) | Â | -0.006 (-0.032, 0.019) | 0.008 (-0.009, 0.025) | 0.013 (-0.013, 0.039) | 0.003 (-0.018, 0.025) | -0.007 (-0.025, 0.011) | 0.006 (-0.024, 0.037) | -0.015 (-0.037, 0.006) | 0.002 (-0.013, 0.018) | -0.002 (-0.027, 0.022) | 0.002 (-0.008, 0.012) | ||
rs7794745 | 0.36(T) | A/A | 3,499 | 0.144 (0.70) | 1,714 | 0.251 (0.72) | 1,785 | 0.041 (0.67) | 0.023 (0.53) | 0.028 (0.54) | 0.019 (0.53) | 0.022 (0.61) | 0.048 (0.63) | -0.004 (0.58) | 0.075 (0.53) | 0.140 (0.55) | 0.013 (0.49) |
 |  | T/A | 3,947 | 0.156 (0.70) | 2,010 | 0.269 (0.71) | 1,937 | 0.039 (0.67) | 0.028 (0.54) | 0.035 (0.56) | 0.021 (0.53) | 0.046 (0.62) | 0.082 (0.66) | 0.009 (0.58) | 0.058 (0.53) | 0.116 (0.56) | -0.001 (0.49) |
 |  | T/T | 1,110 | 0.146 (0.70) | 556 | 0.225 (0.73) | 554 | 0.068 (0.65) | 0.031 (0.53) | 0.020 (0.56) | 0.042 (0.51) | 0.042 (0.63) | 0.067 (0.63) | 0.017 (0.62) | 0.050 (0.51) | 0.111 (0.53) | -0.012 (0.48) |
P valueb | Â | Â | Â | 0.583 | Â | 0.169 | Â | 0.583 | 0.590 | 0.563 | 0.905 | 0.811 | 0.547 | 0.296 | 0.112 | 0.210 | 0.567 |
Effect size (CI 95%)c | Â | -0.006 (-0.028, 0.016) | Â | -0.023 (-0.055, 0.010) | Â | 0.007 (-0.019, 0.034) | 0.005 (-0.012, 0.021) | 0.007 (-0.017, 0.031) | 0.001 (-0.021, 0.023) | 0.002 (-0.014, 0.018) | -0.008 (-0.032, 0.017) | 0.012 (-0.01, 0.034) | -0.012 (-0.026, 0.003) | -0.015 (-0.038, 0.008) | -0.003 (-0.013, 0.007) | ||
RELN | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
rs362691 | 0.13(C) | C/C | 156 | 0.097 (0.68) | 80 | 0.149 (0.69) | 76 | 0.043 (0.66) | -0.065 (0.52) | -0.111 (0.45) | -0.017 (0.58) | 0.097 (0.68) | 0.094 (0.56) | 0.100 (0.78) | 0.087 (0.51) | 0.194 (0.53) | -0.025 (0.46) |
 |  | C/G | 1,823 | 0.126 (0.69) | 874 | 0.270 (0.69) | 949 | -0.007 (0.65) | 0.019 (0.55) | 0.055 (0.57) | -0.015 (0.53) | 0.025 (0.63) | 0.055 (0.66) | -0.002 (0.60) | 0.063 (0.54) | 0.114 (0.58) | 0.016 (0.49) |
 |  | G/G | 6,483 | 0.156 (0.70) | 3,270 | 0.253 (0.72) | 3,213 | 0.058 (0.67) | 0.029 (0.53) | 0.023 (0.55) | 0.036 (0.52) | 0.039 (0.61) | 0.071 (0.65) | 0.006 (0.57) | 0.063 (0.52) | 0.128 (0.55) | -0.002 (0.49) |
P valueb | Â | Â | Â | 0.545 | Â | 0.879 | Â | 0.288 | 0.444 | 0.856 | 0.115 | 0.957 | 0.802 | 0.521 | 0.632 | 0.715 | 0.646 |
Effect size (95% CI)c | Â | -0.010 (-0.041, 0.022) | Â | 0.003 (-0.04, 0.047) | Â | -0.026 (-0.073, 0.022) | -0.009 (-0.033, 0.014) | 0.003 (-0.029, 0.035) | -0.030 (-0.067, 0.007) | 0.001 (-0.023, 0.024) | -0.004 (-0.033, 0.026) | 0.014 (-0.029, 0.056) | 0.005 (-0.016, 0.026) | 0.006 (-0.025, 0.036) | 0.008 (-0.026, 0.042) | ||
SHANK3 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
rs9616915 | 0.49(T) | C/C | 2,170 | 0.149 (0.71) | 1,123 | 0.263 (0.73) | 1,047 | 0.028 (0.65) | 0.039 (0.54) | 0.041 (0.56) | 0.037 (0.52) | 0.020 (0.60) | 0.039 (0.62) | 0.001 (0.58) | 0.060 (0.54) | 0.140 (0.55) | -0.025 (0.51) |
 |  | C/T | 4,182 | 0.161 (0.70) | 2,044 | 0.266 (0.72) | 2,138 | 0.060 (0.66) | 0.037 (0.54) | 0.053 (0.55) | 0.022 (0.53) | 0.039 (0.61) | 0.075 (0.64) | 0.004 (0.58) | 0.057 (0.52) | 0.096 (0.54) | 0.020 (0.49) |
 |  | T/T | 2,061 | 0.120 (0.69) | 1,048 | 0.232 (0.70) | 1,013 | 0.005 (0.66) | -0.010 (0.52) | -0.030 (0.54) | 0.011 (0.50) | 0.042 (0.63) | 0.083 (0.68) | -0.001 (0.57) | 0.081 (0.53) | 0.169 (0.58) | -0.009 (0.46) |
P valueb | Â | Â | Â | 0.703 | Â | 0.870 | Â | 0.716 | 0.152 | 0.068 | 1.00 | 0.377 | 0.308 | 0.994 | 0.273 | 0.266 | 0.659 |
Effect size (CI 95%)c | Â | 0.004 (-0.017, 0.025) | Â | 0.002 (-0.027, .032) | Â | 0.006 (-0.025, 0.037) | -0.012 (-0.028, 0.004) | -0.020 (-0.042, 0.001) | 0.001 (-0.025, 0.025) | 0.007 (-0.009, 0.023) | 0.011 (-0.01, 0.031) | 0.001 (-0.028, 0.028) | 0.008 (-0.006, 0.022) | 0.012 (-0.009, 0.032) | 0.005 (-0.017, 0.028) |