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Table 1 Association between five SNPs and autistic-like traits

From: Association study between autistic-like traits and polymorphisms in the autism candidate regions RELN, CNTNAP2, SHANK3, and CDH9/10

   Autistic-like traitsa Autistic-like traits domains
    Restricted & repetitive behaviora Social interaction impairmenta Language impairmenta
Gene/SNP MAF Genotype N All N Boys N Girls All Boys Girls All Boys Girls All Boys Girls
CDH9/10               
rs4307059 0.37 (C) C/C 1,663 0.68 (1.37) 796 0.86 (1.63) 867 0.50 (1.06) 0.23 (0.57) 0.31 (0.69) 0.16 (0.42) 0.23 (0.57) 0.29 (0.64) 0.18 (0.49) 0.21 (0.52) 0.27 (0.59) 0.16 (0.43)
   T/C 5,564 0.73 (1.44) 2,820 0.91 (1.66) 2,744 0.54 (1.14) 0.23 (0.57) 0.30 (0.66) 0.16 (0.45) 0.25 (0.58) 0.30 (0.64) 0.21 (0.50) 0.24 (0.57) 0.30 (0.65) 0.18 (0.46)
   T/T 4,766 0.67 (1.36) 2,391 0.85 (1.64) 2,375 0.50 (0.98) 0.21 (0.55) 0.28 (0.65) 0.14 (0.40) 0.24 (0.58) 0.29 (0.68) 0.19 (0.45) 0.22 (0.54) 0.27 (0.62) 0.17 (0.44)
P value     0.737   0.634   0.724 0.160 0.302 0.162 0.793 0.762 0.669 0.725 0.704 0.357
Effect size (CI 95%)c   0.007 (-0.033, 0.047)   0.016 (-0.051, 0.083)   0.007 (-0.033, 0.048) 0.011 (-0.004, 0.027) 0.014 (-0.013, 0.041) 0.011 (-0.005, 0.028) -0.002 (-0.018, 0.014) -0.004 (-0.03, 0.022) 0.004 (-0.014, 0.022) 0.003 (-0.019, 0.013) 0.005 (-0.020, 0.030) -0.008 (-0.026, 0.009)
CNTNAP2                  
rs2710102 0.48 (G) A/A 3,248 0.69 (1.37) 1,618 0.87 (1.63) 1,630 0.52 (1.03) 0.22 (0.57) 0.29 (0.68) 0.15 (0.43) 0.25 (0.57) 0.30 (0.65) 0.20 (0.48) 0.22 (0.53) 0.27 (0.61) 0.17 (0.42)
   A/G 5,976 0.70 (1.41) 2,998 0.88 (1.68) 2,978 0.52 (1.04) 0.22 (0.56) 0.29 (0.66) 0.15 (0.42) 0.24 (0.58) 0.29 (0.66) 0.20 (0.47) 0.23 (0.57) 0.29 (0.65) 0.18 (0.46)
   G/G 2,752 0.73 (1.45) 1,382 0.90 (1.60) 1,370 0.55 (1.24) 0.23 (0.58) 0.31 (0.65) 0.16 (0.47) 0.25 (0.58) 0.29 (0.64) 0.21 (0.51) 0.24 (0.56) 0.30 (0.62) 0.18 (0.49)
P value     0.523   0.652   0.727 0.593 0.566 0.880 0.827 0.653 0.766 0.336 0.368 0.542
Effect size (CI 95%)c   0.013 (-0.026, 0.052)   0.015 (-0.050, 0.080)   0.007 (-0.033, 0.048) 0.004 (-0.011, 0.020) 0.008 (-0.018, 0.033) -0.001 (-0.017, 0.015) -0.002 (-0.018, 0.014) -0.006 (-0.031, 0.020) 0.003 (-0.015, 0.020) 0.008 (-0.008, 0.023) 0.011 (-0.013, 0.036) 0.006 (-0.012, 0.023)
rs7794745 0.36 (T) A/A 5,004 0.72 (1.46) 2,475 0.92 (1.73) 2,529 0.53 (1.10) 0.24 (0.60) 0.32 (0.71) 0.16 (0.44) 0.25 (0.59) 0.30 (0.67) 0.19 (0.49) 0.24 (0.57) 0.29 (0.65) 0.19 (0.47)
   T/A 5,533 0.70 (1.41) 2,807 0.87 (1.63) 2,726 0.53 (1.13) 0.22 (0.55) 0.28 (0.63) 0.15 (0.44) 0.26 (0.59) 0.30 (0.66) 0.21 (0.50) 0.23 (0.56) 0.29 (0.64) 0.17 (0.46)
   T/T 1,564 0.67 (1.23) 779 0.82 (1.44) 785 0.51 (0.97) 0.22 (0.52) 0.29 (0.59) 0.15 (0.42) 0.22 (0.50) 0.25 (0.58) 0.20 (0.42) 0.22 (0.51) 0.28 (0.59) 0.16 (0.41)
P value     0.102   0.045b   0.744 0.126 0.081 0.847 0.309 0.050b 0.311 0.182 0.299 0.480
Effect size (CI 95%)c   -0.034 (-0.075, 0.007)   -0.069 (-0.136, -0.001)   0.007 (-0.035, 0.049) -0.013 (-0.029, 0.004) -0.024 (-0.051, 0.003) -0.002 (-0.018, 0.015) -0.009 (-0.025, 0.008) -0.026 (-0.053, <0.001) 0.009 (-0.009, 0.028) -0.011 (-0.027, 0.005) -0.014 (-0.039, 0.012) -0.007 (-0.025, 0.012)
RELN                  
rs362691 0.13 (C) C/C 211 0.65 (1.34) 107 0.66 (1.11) 104 0.63 (1.54) 0.22 (0.56) 0.25 (0.54) 0.18 (0.58) 0.25 (0.55) 0.24 (0.44) 0.25 (0.65) 0.18 (0.45) 0.17 (0.41) 0.20 (0.49)
   C/G 2,629 0.68 (1.39) 1,267 0.89 (1.69) 1,362 0.49 (1.01) 0.21 (0.56) 0.30 (0.68) 0.14 (0.40) 0.24 (0.60) 0.31 (0.71) 0.18 (0.46) 0.22 (0.54) 0.29 (0.61) 0.16 (0.46)
   G/G 9,139 0.71 (1.40) 4,615 0.88 (1.63) 4,524 0.53 (1.09) 0.22 (0.56) 0.29 (0.66) 0.15 (0.43) 0.25 (0.57) 0.29 (0.64) 0.20 (0.48) 0.23 (0.56) 0.29 (0.64) 0.18 (0.45)
P value     0.338   0.629   0.659 0.350 0.739 0.612 0.944 0.835 0.980 0.282 0.306 0.659
Effect size (CI 95%)c   -0.028 (-0.086, 0.03)   -0.024 (-0.12, 0.072)   -0.013 (-0.073, 0.046) -0.011 (-0.034, 0.012) -0.007 (-0.045, 0.032) -0.006 (-0.03, 0.017) -0.001 (-0.024, 0.022) 0.004 (-0.034, 0.042) <0.001 (-0.026, 0.026) -0.013 (-0.036, 0.010) -0.019 (-0.056, 0.018) -0.006 (-0.032, 0.020)
SHANK3                  
rs9616915 0.49 (T) C/C 3,116 0.74 (1.53) 1,589 0.96 (1.84) 1,527 0.52 (1.07) 0.23 (0.60) 0.32 (0.72) 0.14 (0.43) 0.27 (0.62) 0.33 (0.73) 0.20 (0.48) 0.24 (0.58) 0.31 (0.68) 0.18 (0.44)
   C/T 5,839 0.68 (1.32) 2,906 0.83 (1.51) 2,933 0.53 (1.08) 0.22 (0.56) 0.29 (0.65) 0.16 (0.44) 0.24 (0.54) 0.28 (0.60) 0.20 (0.47) 0.22 (0.52) 0.26 (0.58) 0.18 (0.45)
   T/T 2,927 0.68 (1.38) 1,461 0.88 (1.62) 1,466 0.49 (1.04) 0.21 (0.53) 0.29 (0.62) 0.14 (0.41) 0.24 (0.56) 0.28 (0.64) 0.19 (0.48) 0.24 (0.57) 0.31 (0.67) 0.16 (0.45)
P value     0.194   0.425   0.445 0.182 0.274 0.662 0.164 0.184 0.778 0.840 0.637 0.438
Effect size (CI 95%)c   -0.026 (-0.064, 0.013)   -0.026 (-0.089, 0.038)   -0.015 (-0.055, 0.024) -0.010 (-0.026, 0.005) -0.014 (-0.04, 0.011) -0.004 (-0.019, 0.012) -0.011 (-0.027, 0.005) -0.017 (-0.042, 0.008) -0.003 (-0.02, 0.015) -0.002 (-0.017, 0.014) 0.006 (-0.018, 0.030) -0.007 (-0.024, 0.010)
  1. aA-TAC mean values (SD).
  2. bNominal significance, P value <0.05.
  3. cEffect size presented as the regression coefficient (CI 95%).
  4. A-TAC: Autism-Tics, ADHD, and Other Co-morbidities inventory.