|  | Autistic-like traitsa | Autistic-like traits domains | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  |  | Restricted & repetitive behaviora | Social interaction impairmenta | Language impairmenta | ||||||||||||
Gene/SNP | MAF | Genotype | N | All | N | Boys | N | Girls | All | Boys | Girls | All | Boys | Girls | All | Boys | Girls |
CDH9/10 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |||
rs4307059 | 0.37 (C) | C/C | 1,663 | 0.68 (1.37) | 796 | 0.86 (1.63) | 867 | 0.50 (1.06) | 0.23 (0.57) | 0.31 (0.69) | 0.16 (0.42) | 0.23 (0.57) | 0.29 (0.64) | 0.18 (0.49) | 0.21 (0.52) | 0.27 (0.59) | 0.16 (0.43) |
 |  | T/C | 5,564 | 0.73 (1.44) | 2,820 | 0.91 (1.66) | 2,744 | 0.54 (1.14) | 0.23 (0.57) | 0.30 (0.66) | 0.16 (0.45) | 0.25 (0.58) | 0.30 (0.64) | 0.21 (0.50) | 0.24 (0.57) | 0.30 (0.65) | 0.18 (0.46) |
 |  | T/T | 4,766 | 0.67 (1.36) | 2,391 | 0.85 (1.64) | 2,375 | 0.50 (0.98) | 0.21 (0.55) | 0.28 (0.65) | 0.14 (0.40) | 0.24 (0.58) | 0.29 (0.68) | 0.19 (0.45) | 0.22 (0.54) | 0.27 (0.62) | 0.17 (0.44) |
P value | Â | Â | Â | 0.737 | Â | 0.634 | Â | 0.724 | 0.160 | 0.302 | 0.162 | 0.793 | 0.762 | 0.669 | 0.725 | 0.704 | 0.357 |
Effect size (CI 95%)c | Â | 0.007 (-0.033, 0.047) | Â | 0.016 (-0.051, 0.083) | Â | 0.007 (-0.033, 0.048) | 0.011 (-0.004, 0.027) | 0.014 (-0.013, 0.041) | 0.011 (-0.005, 0.028) | -0.002 (-0.018, 0.014) | -0.004 (-0.03, 0.022) | 0.004 (-0.014, 0.022) | 0.003 (-0.019, 0.013) | 0.005 (-0.020, 0.030) | -0.008 (-0.026, 0.009) | ||
CNTNAP2 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
rs2710102 | 0.48 (G) | A/A | 3,248 | 0.69 (1.37) | 1,618 | 0.87 (1.63) | 1,630 | 0.52 (1.03) | 0.22 (0.57) | 0.29 (0.68) | 0.15 (0.43) | 0.25 (0.57) | 0.30 (0.65) | 0.20 (0.48) | 0.22 (0.53) | 0.27 (0.61) | 0.17 (0.42) |
 |  | A/G | 5,976 | 0.70 (1.41) | 2,998 | 0.88 (1.68) | 2,978 | 0.52 (1.04) | 0.22 (0.56) | 0.29 (0.66) | 0.15 (0.42) | 0.24 (0.58) | 0.29 (0.66) | 0.20 (0.47) | 0.23 (0.57) | 0.29 (0.65) | 0.18 (0.46) |
 |  | G/G | 2,752 | 0.73 (1.45) | 1,382 | 0.90 (1.60) | 1,370 | 0.55 (1.24) | 0.23 (0.58) | 0.31 (0.65) | 0.16 (0.47) | 0.25 (0.58) | 0.29 (0.64) | 0.21 (0.51) | 0.24 (0.56) | 0.30 (0.62) | 0.18 (0.49) |
P value | Â | Â | Â | 0.523 | Â | 0.652 | Â | 0.727 | 0.593 | 0.566 | 0.880 | 0.827 | 0.653 | 0.766 | 0.336 | 0.368 | 0.542 |
Effect size (CI 95%)c | Â | 0.013 (-0.026, 0.052) | Â | 0.015 (-0.050, 0.080) | Â | 0.007 (-0.033, 0.048) | 0.004 (-0.011, 0.020) | 0.008 (-0.018, 0.033) | -0.001 (-0.017, 0.015) | -0.002 (-0.018, 0.014) | -0.006 (-0.031, 0.020) | 0.003 (-0.015, 0.020) | 0.008 (-0.008, 0.023) | 0.011 (-0.013, 0.036) | 0.006 (-0.012, 0.023) | ||
rs7794745 | 0.36 (T) | A/A | 5,004 | 0.72 (1.46) | 2,475 | 0.92 (1.73) | 2,529 | 0.53 (1.10) | 0.24 (0.60) | 0.32 (0.71) | 0.16 (0.44) | 0.25 (0.59) | 0.30 (0.67) | 0.19 (0.49) | 0.24 (0.57) | 0.29 (0.65) | 0.19 (0.47) |
 |  | T/A | 5,533 | 0.70 (1.41) | 2,807 | 0.87 (1.63) | 2,726 | 0.53 (1.13) | 0.22 (0.55) | 0.28 (0.63) | 0.15 (0.44) | 0.26 (0.59) | 0.30 (0.66) | 0.21 (0.50) | 0.23 (0.56) | 0.29 (0.64) | 0.17 (0.46) |
 |  | T/T | 1,564 | 0.67 (1.23) | 779 | 0.82 (1.44) | 785 | 0.51 (0.97) | 0.22 (0.52) | 0.29 (0.59) | 0.15 (0.42) | 0.22 (0.50) | 0.25 (0.58) | 0.20 (0.42) | 0.22 (0.51) | 0.28 (0.59) | 0.16 (0.41) |
P value | Â | Â | Â | 0.102 | Â | 0.045b | Â | 0.744 | 0.126 | 0.081 | 0.847 | 0.309 | 0.050b | 0.311 | 0.182 | 0.299 | 0.480 |
Effect size (CI 95%)c | Â | -0.034 (-0.075, 0.007) | Â | -0.069 (-0.136, -0.001) | Â | 0.007 (-0.035, 0.049) | -0.013 (-0.029, 0.004) | -0.024 (-0.051, 0.003) | -0.002 (-0.018, 0.015) | -0.009 (-0.025, 0.008) | -0.026 (-0.053, <0.001) | 0.009 (-0.009, 0.028) | -0.011 (-0.027, 0.005) | -0.014 (-0.039, 0.012) | -0.007 (-0.025, 0.012) | ||
RELN | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
rs362691 | 0.13 (C) | C/C | 211 | 0.65 (1.34) | 107 | 0.66 (1.11) | 104 | 0.63 (1.54) | 0.22 (0.56) | 0.25 (0.54) | 0.18 (0.58) | 0.25 (0.55) | 0.24 (0.44) | 0.25 (0.65) | 0.18 (0.45) | 0.17 (0.41) | 0.20 (0.49) |
 |  | C/G | 2,629 | 0.68 (1.39) | 1,267 | 0.89 (1.69) | 1,362 | 0.49 (1.01) | 0.21 (0.56) | 0.30 (0.68) | 0.14 (0.40) | 0.24 (0.60) | 0.31 (0.71) | 0.18 (0.46) | 0.22 (0.54) | 0.29 (0.61) | 0.16 (0.46) |
 |  | G/G | 9,139 | 0.71 (1.40) | 4,615 | 0.88 (1.63) | 4,524 | 0.53 (1.09) | 0.22 (0.56) | 0.29 (0.66) | 0.15 (0.43) | 0.25 (0.57) | 0.29 (0.64) | 0.20 (0.48) | 0.23 (0.56) | 0.29 (0.64) | 0.18 (0.45) |
P value | Â | Â | Â | 0.338 | Â | 0.629 | Â | 0.659 | 0.350 | 0.739 | 0.612 | 0.944 | 0.835 | 0.980 | 0.282 | 0.306 | 0.659 |
Effect size (CI 95%)c | Â | -0.028 (-0.086, 0.03) | Â | -0.024 (-0.12, 0.072) | Â | -0.013 (-0.073, 0.046) | -0.011 (-0.034, 0.012) | -0.007 (-0.045, 0.032) | -0.006 (-0.03, 0.017) | -0.001 (-0.024, 0.022) | 0.004 (-0.034, 0.042) | <0.001 (-0.026, 0.026) | -0.013 (-0.036, 0.010) | -0.019 (-0.056, 0.018) | -0.006 (-0.032, 0.020) | ||
SHANK3 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
rs9616915 | 0.49 (T) | C/C | 3,116 | 0.74 (1.53) | 1,589 | 0.96 (1.84) | 1,527 | 0.52 (1.07) | 0.23 (0.60) | 0.32 (0.72) | 0.14 (0.43) | 0.27 (0.62) | 0.33 (0.73) | 0.20 (0.48) | 0.24 (0.58) | 0.31 (0.68) | 0.18 (0.44) |
 |  | C/T | 5,839 | 0.68 (1.32) | 2,906 | 0.83 (1.51) | 2,933 | 0.53 (1.08) | 0.22 (0.56) | 0.29 (0.65) | 0.16 (0.44) | 0.24 (0.54) | 0.28 (0.60) | 0.20 (0.47) | 0.22 (0.52) | 0.26 (0.58) | 0.18 (0.45) |
 |  | T/T | 2,927 | 0.68 (1.38) | 1,461 | 0.88 (1.62) | 1,466 | 0.49 (1.04) | 0.21 (0.53) | 0.29 (0.62) | 0.14 (0.41) | 0.24 (0.56) | 0.28 (0.64) | 0.19 (0.48) | 0.24 (0.57) | 0.31 (0.67) | 0.16 (0.45) |
P value | Â | Â | Â | 0.194 | Â | 0.425 | Â | 0.445 | 0.182 | 0.274 | 0.662 | 0.164 | 0.184 | 0.778 | 0.840 | 0.637 | 0.438 |
Effect size (CI 95%)c | Â | -0.026 (-0.064, 0.013) | Â | -0.026 (-0.089, 0.038) | Â | -0.015 (-0.055, 0.024) | -0.010 (-0.026, 0.005) | -0.014 (-0.04, 0.011) | -0.004 (-0.019, 0.012) | -0.011 (-0.027, 0.005) | -0.017 (-0.042, 0.008) | -0.003 (-0.02, 0.015) | -0.002 (-0.017, 0.014) | 0.006 (-0.018, 0.030) | -0.007 (-0.024, 0.010) |