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Table 1 Association between five SNPs and autistic-like traits

From: Association study between autistic-like traits and polymorphisms in the autism candidate regions RELN, CNTNAP2, SHANK3, and CDH9/10

  

Autistic-like traitsa

Autistic-like traits domains

   

Restricted & repetitive behaviora

Social interaction impairmenta

Language impairmenta

Gene/SNP

MAF

Genotype

N

All

N

Boys

N

Girls

All

Boys

Girls

All

Boys

Girls

All

Boys

Girls

CDH9/10

              

rs4307059

0.37 (C)

C/C

1,663

0.68 (1.37)

796

0.86 (1.63)

867

0.50 (1.06)

0.23 (0.57)

0.31 (0.69)

0.16 (0.42)

0.23 (0.57)

0.29 (0.64)

0.18 (0.49)

0.21 (0.52)

0.27 (0.59)

0.16 (0.43)

  

T/C

5,564

0.73 (1.44)

2,820

0.91 (1.66)

2,744

0.54 (1.14)

0.23 (0.57)

0.30 (0.66)

0.16 (0.45)

0.25 (0.58)

0.30 (0.64)

0.21 (0.50)

0.24 (0.57)

0.30 (0.65)

0.18 (0.46)

  

T/T

4,766

0.67 (1.36)

2,391

0.85 (1.64)

2,375

0.50 (0.98)

0.21 (0.55)

0.28 (0.65)

0.14 (0.40)

0.24 (0.58)

0.29 (0.68)

0.19 (0.45)

0.22 (0.54)

0.27 (0.62)

0.17 (0.44)

P value

   

0.737

 

0.634

 

0.724

0.160

0.302

0.162

0.793

0.762

0.669

0.725

0.704

0.357

Effect size (CI 95%)c

 

0.007 (-0.033, 0.047)

 

0.016 (-0.051, 0.083)

 

0.007 (-0.033, 0.048)

0.011 (-0.004, 0.027)

0.014 (-0.013, 0.041)

0.011 (-0.005, 0.028)

-0.002 (-0.018, 0.014)

-0.004 (-0.03, 0.022)

0.004 (-0.014, 0.022)

0.003 (-0.019, 0.013)

0.005 (-0.020, 0.030)

-0.008 (-0.026, 0.009)

CNTNAP2

                 

rs2710102

0.48 (G)

A/A

3,248

0.69 (1.37)

1,618

0.87 (1.63)

1,630

0.52 (1.03)

0.22 (0.57)

0.29 (0.68)

0.15 (0.43)

0.25 (0.57)

0.30 (0.65)

0.20 (0.48)

0.22 (0.53)

0.27 (0.61)

0.17 (0.42)

  

A/G

5,976

0.70 (1.41)

2,998

0.88 (1.68)

2,978

0.52 (1.04)

0.22 (0.56)

0.29 (0.66)

0.15 (0.42)

0.24 (0.58)

0.29 (0.66)

0.20 (0.47)

0.23 (0.57)

0.29 (0.65)

0.18 (0.46)

  

G/G

2,752

0.73 (1.45)

1,382

0.90 (1.60)

1,370

0.55 (1.24)

0.23 (0.58)

0.31 (0.65)

0.16 (0.47)

0.25 (0.58)

0.29 (0.64)

0.21 (0.51)

0.24 (0.56)

0.30 (0.62)

0.18 (0.49)

P value

   

0.523

 

0.652

 

0.727

0.593

0.566

0.880

0.827

0.653

0.766

0.336

0.368

0.542

Effect size (CI 95%)c

 

0.013 (-0.026, 0.052)

 

0.015 (-0.050, 0.080)

 

0.007 (-0.033, 0.048)

0.004 (-0.011, 0.020)

0.008 (-0.018, 0.033)

-0.001 (-0.017, 0.015)

-0.002 (-0.018, 0.014)

-0.006 (-0.031, 0.020)

0.003 (-0.015, 0.020)

0.008 (-0.008, 0.023)

0.011 (-0.013, 0.036)

0.006 (-0.012, 0.023)

rs7794745

0.36 (T)

A/A

5,004

0.72 (1.46)

2,475

0.92 (1.73)

2,529

0.53 (1.10)

0.24 (0.60)

0.32 (0.71)

0.16 (0.44)

0.25 (0.59)

0.30 (0.67)

0.19 (0.49)

0.24 (0.57)

0.29 (0.65)

0.19 (0.47)

  

T/A

5,533

0.70 (1.41)

2,807

0.87 (1.63)

2,726

0.53 (1.13)

0.22 (0.55)

0.28 (0.63)

0.15 (0.44)

0.26 (0.59)

0.30 (0.66)

0.21 (0.50)

0.23 (0.56)

0.29 (0.64)

0.17 (0.46)

  

T/T

1,564

0.67 (1.23)

779

0.82 (1.44)

785

0.51 (0.97)

0.22 (0.52)

0.29 (0.59)

0.15 (0.42)

0.22 (0.50)

0.25 (0.58)

0.20 (0.42)

0.22 (0.51)

0.28 (0.59)

0.16 (0.41)

P value

   

0.102

 

0.045b

 

0.744

0.126

0.081

0.847

0.309

0.050b

0.311

0.182

0.299

0.480

Effect size (CI 95%)c

 

-0.034 (-0.075, 0.007)

 

-0.069 (-0.136, -0.001)

 

0.007 (-0.035, 0.049)

-0.013 (-0.029, 0.004)

-0.024 (-0.051, 0.003)

-0.002 (-0.018, 0.015)

-0.009 (-0.025, 0.008)

-0.026 (-0.053, <0.001)

0.009 (-0.009, 0.028)

-0.011 (-0.027, 0.005)

-0.014 (-0.039, 0.012)

-0.007 (-0.025, 0.012)

RELN

                 

rs362691

0.13 (C)

C/C

211

0.65 (1.34)

107

0.66 (1.11)

104

0.63 (1.54)

0.22 (0.56)

0.25 (0.54)

0.18 (0.58)

0.25 (0.55)

0.24 (0.44)

0.25 (0.65)

0.18 (0.45)

0.17 (0.41)

0.20 (0.49)

  

C/G

2,629

0.68 (1.39)

1,267

0.89 (1.69)

1,362

0.49 (1.01)

0.21 (0.56)

0.30 (0.68)

0.14 (0.40)

0.24 (0.60)

0.31 (0.71)

0.18 (0.46)

0.22 (0.54)

0.29 (0.61)

0.16 (0.46)

  

G/G

9,139

0.71 (1.40)

4,615

0.88 (1.63)

4,524

0.53 (1.09)

0.22 (0.56)

0.29 (0.66)

0.15 (0.43)

0.25 (0.57)

0.29 (0.64)

0.20 (0.48)

0.23 (0.56)

0.29 (0.64)

0.18 (0.45)

P value

   

0.338

 

0.629

 

0.659

0.350

0.739

0.612

0.944

0.835

0.980

0.282

0.306

0.659

Effect size (CI 95%)c

 

-0.028 (-0.086, 0.03)

 

-0.024 (-0.12, 0.072)

 

-0.013 (-0.073, 0.046)

-0.011 (-0.034, 0.012)

-0.007 (-0.045, 0.032)

-0.006 (-0.03, 0.017)

-0.001 (-0.024, 0.022)

0.004 (-0.034, 0.042)

<0.001 (-0.026, 0.026)

-0.013 (-0.036, 0.010)

-0.019 (-0.056, 0.018)

-0.006 (-0.032, 0.020)

SHANK3

                 

rs9616915

0.49 (T)

C/C

3,116

0.74 (1.53)

1,589

0.96 (1.84)

1,527

0.52 (1.07)

0.23 (0.60)

0.32 (0.72)

0.14 (0.43)

0.27 (0.62)

0.33 (0.73)

0.20 (0.48)

0.24 (0.58)

0.31 (0.68)

0.18 (0.44)

  

C/T

5,839

0.68 (1.32)

2,906

0.83 (1.51)

2,933

0.53 (1.08)

0.22 (0.56)

0.29 (0.65)

0.16 (0.44)

0.24 (0.54)

0.28 (0.60)

0.20 (0.47)

0.22 (0.52)

0.26 (0.58)

0.18 (0.45)

  

T/T

2,927

0.68 (1.38)

1,461

0.88 (1.62)

1,466

0.49 (1.04)

0.21 (0.53)

0.29 (0.62)

0.14 (0.41)

0.24 (0.56)

0.28 (0.64)

0.19 (0.48)

0.24 (0.57)

0.31 (0.67)

0.16 (0.45)

P value

   

0.194

 

0.425

 

0.445

0.182

0.274

0.662

0.164

0.184

0.778

0.840

0.637

0.438

Effect size (CI 95%)c

 

-0.026 (-0.064, 0.013)

 

-0.026 (-0.089, 0.038)

 

-0.015 (-0.055, 0.024)

-0.010 (-0.026, 0.005)

-0.014 (-0.04, 0.011)

-0.004 (-0.019, 0.012)

-0.011 (-0.027, 0.005)

-0.017 (-0.042, 0.008)

-0.003 (-0.02, 0.015)

-0.002 (-0.017, 0.014)

0.006 (-0.018, 0.030)

-0.007 (-0.024, 0.010)

  1. aA-TAC mean values (SD).
  2. bNominal significance, P value <0.05.
  3. cEffect size presented as the regression coefficient (CI 95%).
  4. A-TAC: Autism-Tics, ADHD, and Other Co-morbidities inventory.