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Table 2 Adverse events

From: A pilot controlled trial of insulin-like growth factor-1 in children with Phelan-McDermid syndrome

Adverse events IGF-1 Placebo
Constipation 4 3
Sedation 1 0
Decreased appetite 2 3
Periobital/facial swelling 1 0
Diarrhea 1 2
URTIa 5 5
Sleep Disturbance 7 2
Increased appetite 4 0
Mood changes/irritability 4 2
Increased thirst 1 0
Increased phlegm 1 0
Teeth grinding 1 0
Cough 1 2
Hand flapping 1 0
Increased bowel movements 1 0
Increased chewing/biting 1 0
Decreased visual acuity 1 0
Lethargy/decreased energy 1 1
Cooler body temperature/sweating 1 0
Runny nose/congestion 1 1
Gait changes/fell 1 2
Stomach virus 1 1
Anxiety 0 2
Increased urine frequency 2 0
Fever 3 3
Increased energy 1 0
Gagging 1 0
Increased thirst 0 1
Conjunctivitis 1 0
Erythema/swollen eyes 1 0
Vomiting 1 1
Rash 3 0
Nose swelling 1 0
Warmer body temperature 1 0
Hair loss 1 0
Increased aggression 1 0
Hypoglycemiab 7 3
  1. aURTI = upper respiratory tract infection. bHypoglycemia was defined by glucose < 50 mg/dL and occurred in 5/9 patients while on IGF-1 and in 2/9 patients while on placebo.