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Table 2 Correlations of mRNA transcripts with ADI-R scores

From: Dysregulation of estrogen receptor beta (ERβ), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects

  

Social interaction

Verbal communication

Non-verbal communication

Stereotyped behavior

Abnormality of development

ER co-repressors

nCoR

r

–0.021

–0.202

0.479

–0.791

0.063

P

0.961

0.745

0.277

0.019

0.893

Adjusted P

1.000

1.000

1.000

0.095

1.000

SMRT

r

0.013

–0.090

–0.258

–0.489

–0.640

P

0.976

0.866

0.576

0.219

0.122

Adjusted P

1.000

1.000

1.000

0.876

0.610

ER co-activators

CBP

r

–0.549

0.117

0.023

–0.261

–0.718

P

0.126

0.825

0.956

0.498

0.045

Adjusted P

0.504

1.000

1.000

1.000

0.225

P/CAF

r

–0.126

0.540

–0.319

0.515

–0.459

P

0.747

0.268

0.441

0.156

0.253

Adjusted P

1.000

1.000

1.000

0.780

1.000

TIF-2

R

–0.103

0.687

–0.217

0.536

–0.325

P

0.792

0.132

0.606

0.137

0.432

Adjusted P

1.000

0.660

1.000

0.660

1.000

SRC-1

r

–0.109

0.065

–0.876

0.294

–0.774

P

0.798

0.917

0.010

0.480

0.041

Adjusted P

1.000

1.000

0.049

1.000

0.164

AIB-1

r

0.274

0.200

0.099

-0.582

-0.000

 

P

0.475

0.703

0.814

0.099

0.999

 

Adjusted P

1.000

1.000

1.000

0.495

1.000

Estrogen receptor

ERα

r

0.081

–0.210

0.265

–0.157

0.505

P

0.848

0.735

0.566

0.710

0.248

Adjusted P

1.000

1.000

1.000

1.000

1.000

ERβ

r

0.112

–0.203

0.192

–0.215

0.316

P

0.791

0.743

0.680

0.610

0.489

Adjusted P

1.000

1.000

1.000

1.000

1.000

Enzyme

CYP19A1

r

0.405

–0.746

–0.143

–0.227

0.148

P

0.320

0.148

0.760

0.589

0.751

Adjusted P

0.740

1.000

1.000

1.000

1.000

  1. ADI-R scores were available for only 9 of the 13 ASD subjects. Adjusted P denotes P values adjusted using the Holm-Bonferroni sequential correction for multiple comparisons; r, Pearson correlation; P, level of significance. Bolded text indicates significant P values.