Skip to main content

Advertisement

Table 2 Correlations of mRNA transcripts with ADI-R scores

From: Dysregulation of estrogen receptor beta (ERβ), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects

   Social interaction Verbal communication Non-verbal communication Stereotyped behavior Abnormality of development
ER co-repressors
nCoR r –0.021 –0.202 0.479 –0.791 0.063
P 0.961 0.745 0.277 0.019 0.893
Adjusted P 1.000 1.000 1.000 0.095 1.000
SMRT r 0.013 –0.090 –0.258 –0.489 –0.640
P 0.976 0.866 0.576 0.219 0.122
Adjusted P 1.000 1.000 1.000 0.876 0.610
ER co-activators
CBP r –0.549 0.117 0.023 –0.261 –0.718
P 0.126 0.825 0.956 0.498 0.045
Adjusted P 0.504 1.000 1.000 1.000 0.225
P/CAF r –0.126 0.540 –0.319 0.515 –0.459
P 0.747 0.268 0.441 0.156 0.253
Adjusted P 1.000 1.000 1.000 0.780 1.000
TIF-2 R –0.103 0.687 –0.217 0.536 –0.325
P 0.792 0.132 0.606 0.137 0.432
Adjusted P 1.000 0.660 1.000 0.660 1.000
SRC-1 r –0.109 0.065 –0.876 0.294 –0.774
P 0.798 0.917 0.010 0.480 0.041
Adjusted P 1.000 1.000 0.049 1.000 0.164
AIB-1 r 0.274 0.200 0.099 -0.582 -0.000
  P 0.475 0.703 0.814 0.099 0.999
  Adjusted P 1.000 1.000 1.000 0.495 1.000
Estrogen receptor
ERα r 0.081 –0.210 0.265 –0.157 0.505
P 0.848 0.735 0.566 0.710 0.248
Adjusted P 1.000 1.000 1.000 1.000 1.000
ERβ r 0.112 –0.203 0.192 –0.215 0.316
P 0.791 0.743 0.680 0.610 0.489
Adjusted P 1.000 1.000 1.000 1.000 1.000
Enzyme
CYP19A1 r 0.405 –0.746 –0.143 –0.227 0.148
P 0.320 0.148 0.760 0.589 0.751
Adjusted P 0.740 1.000 1.000 1.000 1.000
  1. ADI-R scores were available for only 9 of the 13 ASD subjects. Adjusted P denotes P values adjusted using the Holm-Bonferroni sequential correction for multiple comparisons; r, Pearson correlation; P, level of significance. Bolded text indicates significant P values.