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Figure 2 | Molecular Autism

Figure 2

From: Dysregulation of estrogen receptor beta (ERβ), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects

Figure 2

Decrease in mRNA levels of ER co-activators (SRC-1, CBP, and P/CAF), but no change in ER co-repressors (SMRT and nCoR) in the middle frontal gyrus of ASD subjects. ( A–E ) Normalized mRNA expression of ER co-activators: ( A ) SRC-1, ( B ) CBP, ( C ) P/CAF, ( D ) TIF-2, and ( E ) AIB-1. ( F and G ) Normalized mRNA expression of ER co-repressors: ( F ) SMRT and ( G ) nCoR. mRNA levels were determined by qRT-PCR, and the values were normalized to the geometric mean of two control genes (GAPDH and β-actin). ***P <0.001 vs. controls.

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