Figure 5

Most of the genes differentially expressed in both Angelman syndrome (AS) and isodicentric chromosome 15 (idic(15)) induced pluripotent stem cell (iPSC)-derived neurons compared to normal are changed in the same direction. (a) Venn diagram depicting the number of genes differentially expressed (twofold up or down) between AS (AS del 1-0) and idic(15) (Idic1-8) iPSC-derived neurons compared to normal (Nml 1-0) iPSC-derived neurons. The overlap of the two circles represents the set of shared differentially expressed genes in both AS and idic(15). (b) Heat map showing the mRNA expression levels relative to normal (Nml 1-0) of the top 200 genes differentially expressed in both AS (AS del 1-0) and idic(15)(Idic1-8) iPSC-derived neurons. Genes are clustered according to their similarity in gene expression levels across both samples. Genes colored in yellow show expression levels greater than normal, and genes colored in blue show expression levels less than normal. The trace lines indicate the expression levels of individual genes relative to normal. Normal expression level is indicated by the straight dotted lines.