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Table 1 Summary of metabolic findings in patient MT (Asperger’s) and PL (PDD-NOS)

From: Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene

Patient

Age (years)

5HIAA (nmol/L)

HVA (nmol/L)

HVA/5HIAA (ratio)

Serotonin

     

Blood (ng/mL)

Platelets (ng/×109)

MT

9.6

64.7

389.6

6.0

287

1041

PL

6.2

73.6

399.8

5.4

221

675

Ref*

5–10*

133 (88–178)*

523 (144–801)*

1.5–3.5*

50–220**

125–500**

  1. HVA, homovanillic acid; 5HIAA, 5-hydroxyindolacetic acid (serotonin end-metabolite).
  2. *Reference values and ranges see ref. [33].
  3. **Reference values see ref. [34].
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Molecular Autism

ISSN: 2040-2392