Frontal Cortex | Hippocampus | |||||||||||||||
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Biological Pathway/Function | UP-ID | Gene name | M | TPP | Ratio NR1/Wt | P | P* | LC-MSE | TPP | Ratio NR1/Wt | P | P* | LC-MSE | |||
Purine metabolism | ||||||||||||||||
Pathway analysis (LC-MSE) | not annotated | PSEA: â–² Purine metabolism | ||||||||||||||
IPA: â–² Concentration of ATP | ||||||||||||||||
Hypoxanthine-guanine phosphoribosyltransferase | P00493 | Hprt1 | 3 | 5|4 | not significant | 4|4 | 1.24 | â–² | 0.0054 | 0.018 | ||||||
1 | 4|5 | 6|4 | 1.22 | ▲ | 1.8 × 10-15 | 1.4 × 10-14 | ||||||||||
Glycolysis/Gluconeogenesis/Tricarbon acid cycle | ||||||||||||||||
Pathway analysis (LC-MSE) | IPA: Metabolism of NADH | |||||||||||||||
PSEA: TCA cycle | ||||||||||||||||
Aspartate aminotransferase, mito. | P05202 | Got2 | 3 | 5|4 | 1.15 | ▲ | 3.5 × 10-05 | 4.4 × 10-04 | 5|7 | 1.15 | ▲ | <×10-16 | <×10-16 | |||
1 | 5|7 | 1.12 | ▲ | 8.9 × 10-16 | 1.1 × 10-14 | 5|5 | 1.18 | ▲ | 1.2 × 10-07 | 7.1 × 10-07 | ||||||
Pyruvate kinase, mito. | P52480 | Pkm | 3 | 4|5 | 1.17 | ▲ | 0.0007 | 0.0059 | 4|5 | 1.26 | ▲ | 1.3 × 10-06 | 8.3 × 10-06 | ▲*** | ||
2 | 5|7 | 1.13 | ▲ | 1.4 × 10-08 | 1.6 × 10-07 | 4|7 | 1.07 | ▲ | 0.0028 | 0.0158 | ||||||
NADH-ubiquinone oxidoreductase 75 kDa subunit, mito. | Q91VD9 | Ndufs1 | 1 | 4|4 | 1.18 | ▲ | 0.001 | 0.005 | 8|4 | 1.28 | ▲ | <×10-16 | <×10-16 | |||
Neurotransmitter metabolism/transport | ||||||||||||||||
Pathway analysis (LC-MSE) | IPA: Transport of amino acids | not annotated | ||||||||||||||
IPA: Transport of L-glutamic acid | ||||||||||||||||
Proline dehydrogenase 1, mito. | Q9WU79 | Prodh | 3 | 5|4 | not significant | 2|2 | not significant | |||||||||
1 | 2|2 | 4|3 | ||||||||||||||
Catechol O-methyltransferase | O88587 | Comt | 1 | 4|2 | not significant | 3|3 | not significant | |||||||||
Glutamate decarboxylase 2 | P48320 | Gad2 | 2 | 3|4 | 1.25 | â–² | 0.0004 | 0.0015 | 3|4 | not significant | ||||||
Vesicular glutamate transporter 1 (VGluT1) | Q3TXX4 | Slc17a7 | 3 | 5 | 1.14 | â–² | 0.0031 | 0.0192 | 5 | not significant | ||||||
1 | 6 | 1.20 | ▲ | <×10-16 | <×10-16 | 4|6 | not significant | |||||||||
4-aminobutyrate aminotransferase, mito | P61922 | Abat | 2 | 4|6 | 1.14 | â–² | 0.0006 | 0.0024 | 4|5 | not significant | ||||||
Clathrin-mediated exo-/endocytosis | ||||||||||||||||
Pathway analysis (LC-MSE) | PSEA: â–² Vesicle coating, â–² Membrane budding | not annotated | ||||||||||||||
PSEA: â–² Clathrin coated pit etc. | ||||||||||||||||
IPA: â–² Formation of artificial clathrin cages | ||||||||||||||||
AP-2 complex subunit alpha-1 | P17426 | Ap2a1 | 1 | 5|6 | 1.13 | ▲ | 6.5 × 10-08 | 5.2 × 10-07 | 6|6 | not significant | ▲* | |||||
Synaptojanin | Q8CHC4 | Synj | 2 | 3|5|3 | 1.08 | â–² | 0.017 | 0.041 | 5|5|5 | not significant | ||||||
Synapsin-1 | O88935 | Syn1 | 2 | 6|4|3 | 1.11 | â–² | 0.005 | 0.016 | 6|4|3 | not significant | ||||||
Synaptotagmin-1 | P46096 | Syt1 | 2 | 6|7 | 1.09 | â–² | 0.001 | 0.004 | 5|6 | 1.11 | â–² | 0.0016 | 0.0112 | â–²** | ||
Neurotransmitter receptors | ||||||||||||||||
N-methyl-D-aspartate receptor subunit NR1 | P35438 | Grin1 | 3 | 6 | 0.26 | ▼ | <×10-16 | <×10-16 | 3|2 | 0.16 | ▼ | <E-16 | <E-16 | |||
Glutamate receptor 1 (GluR-1) | P23818 | Gria1 | 3 | 4|3 | not significant | 4 | not significant | |||||||||
Glutamate receptor 2 (GluR-2) | P23819 | Gria2 | 3 | 5|4|4|4 | not significant | 4|3 | not significant | |||||||||
Glutamate receptor 3 (GluR-3) | Q9Z2W9 | Gria3 | 3 | 4|2 | not significant | 3|4|3|4 | not significant | |||||||||
Long-term potentiation/Signal transduction | ||||||||||||||||
Pathway analysis (LC-MSE) | IPA: â–¼ Long term potentiation (of synapse) | IPA: â–¼ Long term potentiation | ||||||||||||||
PSEA: â–¼ Long term potentiation | ||||||||||||||||
PSEA: â–¼ EBB-signalling pathway | ||||||||||||||||
CaM kinase II subunit alpha | P11798 | Camk2a | 3 | 3|4 | 0.90 | â–¼ | 0.0006 | 0.0056 | â–¼*** | 3|5 | not significant | â–¼* | ||||
CaM kinase II subunit beta | P28652 | Camk2b | 1 | 6|6 | not significant | 6|6 | 0.89 | ▼ | 1.5 × 10-08 | 1.2 × 10-07 | ||||||
2 | 6|6 | 6|6 | 0.96 | ▼ | 3.6 × 10-05 | 1.7 × 10-04 | ||||||||||
3 | 5|4 | 6|7 | 0.89 | ▼ | 1.5 × 10-08 | 1.2 × 10-07 | ||||||||||
CaM kinase II subunit gamma | Q923T9 | Camk2g | 3 | 4|4 | not significant | â–¼*** | 4|4 | not significant | ||||||||
Calcineurin subunit B type 1 | Q63810 | Ppp3r1 | 2 | 6|6 | 0.90 | â–¼ | 0.0002 | 0.001 | 7|6 | not significant | ||||||
Ser/thr-protein phosphatase 2B cat. subunit β | P48453 | Ppp3cb | 2 | 5|2 | 1.11 | ▲ | 0.012 | 0.032 | 5|2 | not significant | ||||||
Neurochondrin | Q9Z0E0 | Ncdn | 3 | 4|3 | 1.21 | â–² | 0.017 | 0.083 | 4|4 | not significant | ||||||
1 | 4|3 | 1.16 | â–² | 0.001 | 0.005 | 3|3 | â–¼** | |||||||||
Disks large homolog 4 (PSD-95) | Q62108 | Dlg4 | 3 | 5|4 | not significant | 4|5 | 1.18 | â–² | 0.0004 | 0.0015 | ||||||
1 | 4|3 | 1.15 | â–² | 0.0032 | 0.0099 | 4|3 | not significant | |||||||||
ERK-Pathway | ||||||||||||||||
Pathway analysis | IPA: Implicated in top network | IPA: Implicated in top network | ||||||||||||||
Astrocytic phosphoprotein PEA-15 | Q62048 | Pea15 | 3 | 5|4 | 1.09 | â–² | 0.10 | 0.33 | 6|4 | 1.12 | â–² | 0.007 | 0.021 | â–²(*) | ||
1 | 8 | 1.12 | ▲ | 0.001 | 0.005 | 8|9 | 1.20 | ▲ | <×10-16 | <×10-16 | ||||||
Mitogen-activated protein kinase 1 (ERK-2 ) | P63085 | Erk2 | 3 | 5|5 | 1.07 | â–² | 0.04 | 0.13 | 6|5 | 1.12 | â–² | 0.0002 | 0.0009 | |||
2 | 4|6|6 | 1.16 | ▲ | 9.8 × 10-10 | 1.7 × 10-08 | 4|6|6 | 0.94 | ▲ | 0.0202 | 0.0685 | ||||||
Mitogen-activated protein kinase 3 (ERK-1) | Q63844 | Erk1 | 3 | 4|4|4 | 1.10 | â–² | 0.03 | 0.11 | 4|4|4 | 1.14 | â–² | 0.0004 | 0.0015 | |||
Actin cytoskeleton/cell morphology/structural elements | ||||||||||||||||
Pathway analysis (LC-MSE) | amongst others: | IPA: â–¼ Organisation of cytoskeleton | IPA: â–² Formation plasma membrane projections | |||||||||||||
IPA: â–¼ Organisation of cytoplasm | IPA: â–² Microtubuli dynamics | |||||||||||||||
IPA: Degeneration of axons | IPA: â–² Organisation of cytoskeleton | |||||||||||||||
PSEA: â–² Neuronal projection membrane | IPA: â–²Organisation of cellular protrusions | |||||||||||||||
PSEA: â–² Regulation of synaptic plasticity | ||||||||||||||||
PSEA: â–² Neg. regulation of cell differentiation | ||||||||||||||||
PSEA: â–² Neg. regulation of cell death/apoptosis | ||||||||||||||||
PSEA: â–¼ Extracellular matrix/space | ||||||||||||||||
Myristoylated alanine-rich C-kinase substrate | P26645 | Marcks | 2 | 6|2|4 | 1.22 | ▲ | 8.4 × 10-05 | 5.7 × 10-04 | ▲*** | 4|4|6 | 1.41 | ▲ | 1.1 × 10-08 | 1.1 × 10-07 | ▲(*) | |
3 | 4|4|6 | not significant | 6|3|4 | 1.32 | ▲ | 2.3 × 10-10 | 8.0 × 10-09 | |||||||||
PKC and casein kinase substrate in neurons protein 1 | Q61644 | Pacsin1 | 3 | 6|4 | not significant | 6|3 | 1.28 | ▲ | 2.9 × 10-09 | 3.6 × 10-08 | ▼** | |||||
Methionine aminopeptidase 2 (MAP 2) | O08663 | Metap2 | 3 | 5|4 | not significant | 5|3 | 1.28 | ▲ | 1.6 × 10-07 | 1.1 × 10-06 | ||||||
Neurofilament light polypeptide (NF-L) | P08551 | Nefl | 2 | 3|4|3 | not significant | 3|4|3 | 1.13 | â–² | 0.0010 | 0.0086 | ||||||
Vesicle-fusing ATPase | P46460 | Nsf | 3 | 5|6|6 | 1.07 | â–² | 0.008 | 0.047 | 5|6|5 | 1.10 | â–² | 0.0005 | 0.0018 | |||
2 | 6|5|4 | 1.10 | ▲ | 2.0 × 10-07 | 1.7 × 10-06 | 6|5|4 | not significant | |||||||||
Neuromodulin (Axonal membrane protein GAP-43) | P06837 | Gap43 | 2 | 5|6 | 1.21 | â–² | 0.008 | 0.022 | 6 | 1.21 | â–² | 0.008 | 0.038 | |||
Neural cell adhesion molecule 1 (N-CAM-1) | P13595 | Ncam1 | 2 | 6|5|3 | 1.11 | â–² | 0.0003 | 0.001 | 6|5|3 | 1.11 | â–² | 0.0003 | 0.003 | |||
2’,3’-cyclic-nucleotide 3’-phosphodiesterase (CNPase) | P16330 | Cnp | 3 | 5|3|3 | 0.84 | ▼ | 0.024 | 0.108 | 4|3|5 | not significant | ▼* | |||||
Myelin basic protein (MBP) | P04370 | Mbp | 3 | 5 | 0.87 | ▼ | 1.7 × 10-05 | 0.0003 | 5 | not significant | ||||||
2 | 5 | not significant | 5 | 0.93 | â–¼ | 0.0127 | 0.0479 | |||||||||
Myelin proteolipid protein (PLP) | P60202 | Plp1 | 3 | 5|4|4 | 0.87 | ▼ | 1.2 × 10-07 | 3.0 × 10-06 | ▼*** | 5|4|4 | 1.11 | ▲ | 0.0001 | 0.0005 | ▼* | |
2 | 6|7|7 | 0.87 | ▼ | <×10-16 | <×10-16 | 6|7|6 | 0.96 | ▼ | 0.0123 | 0.0479 | ||||||
Glial fibrillary acidic protein (GFAP) | P03995 | Gfap | 3 | 3|4 | 1.23 | ▲ | 0.002 | 0.017 | 3|4 | 1.29 | ▲ | 1.8 × 10-06 | 9.9 × 10-06 | ▲* | ||
Coronin-1A (Coronin-like protein A) | O89053 | Coro1a | 1 | 5|5 | 1.11 | â–² | 0.003 | 0.010 | 5|5 | not significant |