Purine metabolism
| | | | | | | | | | | | | | | |
|
Pathway analysis (LC-MSE)
| | | | |
not annotated
| |
PSEA: ▲ Purine metabolism
|
| | | | | |
IPA: ▲ Concentration of ATP
|
|
Hypoxanthine-guanine phosphoribosyltransferase
|
P00493
|
Hprt1
|
3
|
5|4
|
not significant
| |
4|4
|
1.24
|
▲
|
0.0054
|
0.018
| |
|
1
|
4|5
| |
6|4
|
1.22
|
▲
|
1.8 × 10-15
|
1.4 × 10-14
| |
Glycolysis/Gluconeogenesis/Tricarbon acid cycle
| | | | | | | | | | | | | | |
|
Pathway analysis (LC-MSE)
| | | | | | | | |
IPA: Metabolism of NADH
|
| | | | | |
PSEA: TCA cycle
|
|
Aspartate aminotransferase, mito.
|
P05202
|
Got2
|
3
|
5|4
|
1.15
|
▲
|
3.5 × 10-05
|
4.4 × 10-04
| |
5|7
|
1.15
|
▲
|
<×10-16
|
<×10-16
| |
|
1
|
5|7
|
1.12
|
▲
|
8.9 × 10-16
|
1.1 × 10-14
| |
5|5
|
1.18
|
▲
|
1.2 × 10-07
|
7.1 × 10-07
| |
|
Pyruvate kinase, mito.
|
P52480
|
Pkm
|
3
|
4|5
|
1.17
|
▲
|
0.0007
|
0.0059
| |
4|5
|
1.26
|
▲
|
1.3 × 10-06
|
8.3 × 10-06
|
▲***
|
|
2
|
5|7
|
1.13
|
▲
|
1.4 × 10-08
|
1.6 × 10-07
| |
4|7
|
1.07
|
▲
|
0.0028
|
0.0158
|
|
NADH-ubiquinone oxidoreductase 75 kDa subunit, mito.
|
Q91VD9
|
Ndufs1
|
1
|
4|4
|
1.18
|
▲
|
0.001
|
0.005
| |
8|4
|
1.28
|
▲
|
<×10-16
|
<×10-16
| |
Neurotransmitter metabolism/transport
| | | | | | | | | | | | | | | |
|
Pathway analysis (LC-MSE)
| | | |
IPA: Transport of amino acids
| |
not annotated
| |
| | | |
IPA: Transport of L-glutamic acid
| | |
|
Proline dehydrogenase 1, mito.
|
Q9WU79
|
Prodh
|
3
|
5|4
|
not significant
| |
2|2
|
not significant
| |
|
1
|
2|2
| |
4|3
| |
|
Catechol O-methyltransferase
|
O88587
|
Comt
|
1
|
4|2
|
not significant
| |
3|3
|
not significant
| |
|
Glutamate decarboxylase 2
|
P48320
|
Gad2
|
2
|
3|4
|
1.25
|
▲
|
0.0004
|
0.0015
| |
3|4
|
not significant
| |
|
Vesicular glutamate transporter 1 (VGluT1)
|
Q3TXX4
|
Slc17a7
|
3
|
5
|
1.14
|
▲
|
0.0031
|
0.0192
| |
5
|
not significant
| |
|
1
|
6
|
1.20
|
▲
|
<×10-16
|
<×10-16
| |
4|6
|
not significant
| |
|
4-aminobutyrate aminotransferase, mito
|
P61922
|
Abat
|
2
|
4|6
|
1.14
|
▲
|
0.0006
|
0.0024
| |
4|5
|
not significant
| |
Clathrin-mediated exo-/endocytosis
| | | | | | | | | | | | | | | |
|
Pathway analysis (LC-MSE)
| | | |
PSEA: ▲ Vesicle coating, ▲ Membrane budding
| |
not annotated
| |
| | | |
PSEA: ▲ Clathrin coated pit etc.
| | |
| | | |
IPA: ▲ Formation of artificial clathrin cages
| | |
|
AP-2 complex subunit alpha-1
|
P17426
|
Ap2a1
|
1
|
5|6
|
1.13
|
▲
|
6.5 × 10-08
|
5.2 × 10-07
| |
6|6
|
not significant
|
▲*
|
|
Synaptojanin
|
Q8CHC4
|
Synj
|
2
|
3|5|3
|
1.08
|
▲
|
0.017
|
0.041
| |
5|5|5
|
not significant
| |
|
Synapsin-1
|
O88935
|
Syn1
|
2
|
6|4|3
|
1.11
|
▲
|
0.005
|
0.016
| |
6|4|3
|
not significant
| |
|
Synaptotagmin-1
|
P46096
|
Syt1
|
2
|
6|7
|
1.09
|
▲
|
0.001
|
0.004
| |
5|6
|
1.11
|
▲
|
0.0016
|
0.0112
|
▲**
|
Neurotransmitter receptors
| | | | | | | | | | | | | | | |
|
N-methyl-D-aspartate receptor subunit NR1
|
P35438
|
Grin1
|
3
|
6
|
0.26
|
▼
|
<×10-16
|
<×10-16
| |
3|2
|
0.16
|
▼
|
<E-16
|
<E-16
| |
|
Glutamate receptor 1 (GluR-1)
|
P23818
|
Gria1
|
3
|
4|3
|
not significant
| |
4
|
not significant
| |
|
Glutamate receptor 2 (GluR-2)
|
P23819
|
Gria2
|
3
|
5|4|4|4
|
not significant
| |
4|3
|
not significant
| |
|
Glutamate receptor 3 (GluR-3)
|
Q9Z2W9
|
Gria3
|
3
|
4|2
|
not significant
| |
3|4|3|4
|
not significant
| |
Long-term potentiation/Signal transduction
| | | | | | | | | | | | | | | |
|
Pathway analysis (LC-MSE)
| | | |
IPA: ▼ Long term potentiation (of synapse)
|
IPA: ▼ Long term potentiation
|
| | | | PSEA: ▼ Long term potentiation | |
| | | |
PSEA: ▼ EBB-signalling pathway
| | |
|
CaM kinase II subunit alpha
|
P11798
|
Camk2a
|
3
|
3|4
|
0.90
|
▼
|
0.0006
|
0.0056
|
▼***
|
3|5
|
not significant
|
▼*
|
|
CaM kinase II subunit beta
|
P28652
|
Camk2b
|
1
|
6|6
|
not significant
| |
6|6
|
0.89
|
▼
|
1.5 × 10-08
|
1.2 × 10-07
| |
|
2
|
6|6
| |
6|6
|
0.96
|
▼
|
3.6 × 10-05
|
1.7 × 10-04
| |
|
3
|
5|4
| |
6|7
|
0.89
|
▼
|
1.5 × 10-08
|
1.2 × 10-07
| |
|
CaM kinase II subunit gamma
|
Q923T9
|
Camk2g
|
3
|
4|4
|
not significant
|
▼***
|
4|4
|
not significant
| |
|
Calcineurin subunit B type 1
|
Q63810
|
Ppp3r1
|
2
|
6|6
|
0.90
|
▼
|
0.0002
|
0.001
| |
7|6
|
not significant
| |
|
Ser/thr-protein phosphatase 2B cat. subunit β
|
P48453
|
Ppp3cb
|
2
|
5|2
|
1.11
|
▲
|
0.012
|
0.032
| |
5|2
|
not significant
| |
|
Neurochondrin
|
Q9Z0E0
|
Ncdn
|
3
|
4|3
|
1.21
|
▲
|
0.017
|
0.083
| |
4|4
|
not significant
| |
|
1
|
4|3
|
1.16
|
▲
|
0.001
|
0.005
| |
3|3
|
▼**
|
|
Disks large homolog 4 (PSD-95)
|
Q62108
|
Dlg4
|
3
|
5|4
|
not significant
| |
4|5
|
1.18
|
▲
|
0.0004
|
0.0015
| |
|
1
|
4|3
|
1.15
|
▲
|
0.0032
|
0.0099
| |
4|3
|
not significant
| |
ERK-Pathway
| | | | | | | | | | | | | | | |
|
Pathway analysis
| | | |
IPA: Implicated in top network
|
IPA: Implicated in top network
|
|
Astrocytic phosphoprotein PEA-15
|
Q62048
|
Pea15
|
3
|
5|4
|
1.09
|
▲
|
0.10
|
0.33
| |
6|4
|
1.12
|
▲
|
0.007
|
0.021
|
▲(*)
|
|
1
|
8
|
1.12
|
▲
|
0.001
|
0.005
| |
8|9
|
1.20
|
▲
|
<×10-16
|
<×10-16
| |
|
Mitogen-activated protein kinase 1 (ERK-2 )
|
P63085
|
Erk2
|
3
|
5|5
|
1.07
|
▲
|
0.04
|
0.13
| |
6|5
|
1.12
|
▲
|
0.0002
|
0.0009
| |
|
2
|
4|6|6
|
1.16
|
▲
|
9.8 × 10-10
|
1.7 × 10-08
| |
4|6|6
|
0.94
|
▲
|
0.0202
|
0.0685
| |
|
Mitogen-activated protein kinase 3 (ERK-1)
|
Q63844
|
Erk1
|
3
|
4|4|4
|
1.10
|
▲
|
0.03
|
0.11
| |
4|4|4
|
1.14
|
▲
|
0.0004
|
0.0015
| |
Actin cytoskeleton/cell morphology/structural elements
| | | | | | | | | |
|
Pathway analysis (LC-MSE)
|
amongst others:
| |
IPA: ▼ Organisation of cytoskeleton
|
IPA: ▲ Formation plasma membrane projections
|
| | | |
IPA: ▼ Organisation of cytoplasm
|
IPA: ▲ Microtubuli dynamics
|
| | | |
IPA: Degeneration of axons
|
IPA: ▲ Organisation of cytoskeleton
|
| | | |
PSEA: ▲ Neuronal projection membrane
|
IPA: ▲Organisation of cellular protrusions
|
| | | | |
PSEA: ▲ Regulation of synaptic plasticity
|
| | | | |
PSEA: ▲ Neg. regulation of cell differentiation
|
| | | | |
PSEA: ▲ Neg. regulation of cell death/apoptosis
|
| | | | |
PSEA: ▼ Extracellular matrix/space
|
|
Myristoylated alanine-rich C-kinase substrate
|
P26645
|
Marcks
|
2
|
6|2|4
|
1.22
|
▲
|
8.4 × 10-05
|
5.7 × 10-04
|
▲***
|
4|4|6
|
1.41
|
▲
|
1.1 × 10-08
|
1.1 × 10-07
|
▲(*)
|
|
3
|
4|4|6
|
not significant
|
6|3|4
|
1.32
|
▲
|
2.3 × 10-10
|
8.0 × 10-09
|
|
PKC and casein kinase substrate in neurons protein 1
|
Q61644
|
Pacsin1
|
3
|
6|4
|
not significant
| |
6|3
|
1.28
|
▲
|
2.9 × 10-09
|
3.6 × 10-08
|
▼**
|
|
Methionine aminopeptidase 2 (MAP 2)
|
O08663
|
Metap2
|
3
|
5|4
|
not significant
| |
5|3
|
1.28
|
▲
|
1.6 × 10-07
|
1.1 × 10-06
| |
|
Neurofilament light polypeptide (NF-L)
|
P08551
|
Nefl
|
2
|
3|4|3
|
not significant
| |
3|4|3
|
1.13
|
▲
|
0.0010
|
0.0086
| |
|
Vesicle-fusing ATPase
|
P46460
|
Nsf
|
3
|
5|6|6
|
1.07
|
▲
|
0.008
|
0.047
| |
5|6|5
|
1.10
|
▲
|
0.0005
|
0.0018
| |
|
2
|
6|5|4
|
1.10
|
▲
|
2.0 × 10-07
|
1.7 × 10-06
| |
6|5|4
|
not significant
| |
|
Neuromodulin (Axonal membrane protein GAP-43)
|
P06837
|
Gap43
|
2
|
5|6
|
1.21
|
▲
|
0.008
|
0.022
| |
6
|
1.21
|
▲
|
0.008
|
0.038
| |
|
Neural cell adhesion molecule 1 (N-CAM-1)
|
P13595
|
Ncam1
|
2
|
6|5|3
|
1.11
|
▲
|
0.0003
|
0.001
| |
6|5|3
|
1.11
|
▲
|
0.0003
|
0.003
| |
|
2’,3’-cyclic-nucleotide 3’-phosphodiesterase (CNPase)
|
P16330
|
Cnp
|
3
|
5|3|3
|
0.84
|
▼
|
0.024
|
0.108
| |
4|3|5
|
not significant
|
▼*
|
|
Myelin basic protein (MBP)
|
P04370
|
Mbp
|
3
|
5
|
0.87
|
▼
|
1.7 × 10-05
|
0.0003
| |
5
|
not significant
| |
|
2
|
5
|
not significant
| |
5
|
0.93
|
▼
|
0.0127
|
0.0479
| |
|
Myelin proteolipid protein (PLP)
|
P60202
|
Plp1
|
3
|
5|4|4
|
0.87
|
▼
|
1.2 × 10-07
|
3.0 × 10-06
|
▼***
|
5|4|4
|
1.11
|
▲
|
0.0001
|
0.0005
|
▼*
|
|
2
|
6|7|7
|
0.87
|
▼
|
<×10-16
|
<×10-16
|
6|7|6
|
0.96
|
▼
|
0.0123
|
0.0479
|
|
Glial fibrillary acidic protein (GFAP)
|
P03995
|
Gfap
|
3
|
3|4
|
1.23
|
▲
|
0.002
|
0.017
| |
3|4
|
1.29
|
▲
|
1.8 × 10-06
|
9.9 × 10-06
|
▲*
|
|
Coronin-1A (Coronin-like protein A)
|
O89053
|
Coro1a
|
1
|
5|5
|
1.11
|
▲
|
0.003
|
0.010
| |
5|5
|
not significant
| |