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Table 2 Comparison of the combined frequency of rare variants between the patient and control groups

From: Genetic analysis of GABRB3 as a candidate gene of autism spectrum disorders

Rare variants

Patients (n = 356)

Control (n = 386)

Odds ratio

P

 

All rare variants

18

6

3.37

0.007

 

5′ regulatory region

7

0

 

0.006

Fisher’s exact test

Intronic regions

4

2

2.18

0.36

 

Exonic regions

8

4

2.20

0.19

 
  1. A patient had multiple mutations at the 5′ regulatory and a T186M missense mutation; hence, a total of 14 patients had the rare mutations.