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Table 1 Genotype and allele frequencies of the six known SNPs and association analysis between the patient (n = 356) and control (n = 386) groups

From: Genetic analysis of GABRB3 as a candidate gene of autism spectrum disorders

Location SNP ID Group Allele (1/2) Genotype counts (frequency) P(df = 2) Allele counts (frequency) P(df = 1) Power (df = .1)
1/1 1/2 2/2 1 2
5′ region rs4906902 ASD T/C 168 (0.472) 140 (0.393) 48 (0.135) 0.304 476 (0.669) 236 (0.332) 0.226 37.4%
Control 161 (0.417) 171 (0.443) 54 (0.140) 493 (0.639) 279 (0.361)  
rs8179184 ASD G/A 168 (0.472) 141 (0.396) 47 (0.132) 0.342 477 (0.670) 235 (0.330) 0.244 37.3%
Control 162 (0.420) 171 (0.443) 53 (0.137) 495 (0.641) 277 (0.359)  
rs20317 ASD C/G 167 (0.470) 140 (0.393) 49 (0.138) 0.327 474 (0.666) 238 (0.334) 0.347 37.6%
Control 162 (0.420) 172 (0.446) 52 (0.135) 496 (0.643) 276 (0.357)  
Exon 1a rs20318 ASD C/T 167 (0.470) 139 (0.390) 50 (0.140) 0.220 473 (0.664) 239 (0.336) 0.406 37.7%
Control 161 (0.417) 175 (0.453) 50 (0.130) 497 (0.644) 275 (0.356)  
Intron 3 rs8179186 ASD C/T 168 (0.472) 141 (0.396) 47 (0.132) 0.367 477 (0.670) 235 (0.330) 0.289 37.4%
Control 163 (0.422) 171 (0.443) 52 (0.135) 497 (0.644) 275 (0.356)  
Intron 8 rs3751582 ASD G/A 195 (0.548) 126 (0.354) 35 (0.098) 0.013 516 (0.725) 196 (0.275) 0.131 34.0%
Control 217 (0.562) 152 (0.394) 17 (0.044) 586 (0.759) 186 (0.241)  
  1. Power indicates the estimates of power of risk alleles to detect the association with ASD under the assumptions of multiplicative inheritance mode, genotype relative risk (Aa) = 1.2, prevalence of disease = 0.01, D’ = 1 and P-value of 0.05 under null hypothesis. df indicates degree of freedom. ASD, autism spectrum disorders.