Table 1 Genotype and allele frequencies of the six known SNPs and association analysis between the patient (n = 356) and control (n = 386) groups
From: Genetic analysis of GABRB3 as a candidate gene of autism spectrum disorders
Location | SNP ID | Group | Allele (1/2) | Genotype counts (frequency) | P(df = 2) | Allele counts (frequency) | P(df = 1) | Power (df = .1) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
1/1 | 1/2 | 2/2 | 1 | 2 | |||||||
5′ region | rs4906902 | ASD | T/C | 168 (0.472) | 140 (0.393) | 48 (0.135) | 0.304 | 476 (0.669) | 236 (0.332) | 0.226 | 37.4% |
Control | 161 (0.417) | 171 (0.443) | 54 (0.140) | 493 (0.639) | 279 (0.361) | Â | |||||
rs8179184 | ASD | G/A | 168 (0.472) | 141 (0.396) | 47 (0.132) | 0.342 | 477 (0.670) | 235 (0.330) | 0.244 | 37.3% | |
Control | 162 (0.420) | 171 (0.443) | 53 (0.137) | 495 (0.641) | 277 (0.359) | Â | |||||
rs20317 | ASD | C/G | 167 (0.470) | 140 (0.393) | 49 (0.138) | 0.327 | 474 (0.666) | 238 (0.334) | 0.347 | 37.6% | |
Control | 162 (0.420) | 172 (0.446) | 52 (0.135) | 496 (0.643) | 276 (0.357) | Â | |||||
Exon 1a | rs20318 | ASD | C/T | 167 (0.470) | 139 (0.390) | 50 (0.140) | 0.220 | 473 (0.664) | 239 (0.336) | 0.406 | 37.7% |
Control | 161 (0.417) | 175 (0.453) | 50 (0.130) | 497 (0.644) | 275 (0.356) | Â | |||||
Intron 3 | rs8179186 | ASD | C/T | 168 (0.472) | 141 (0.396) | 47 (0.132) | 0.367 | 477 (0.670) | 235 (0.330) | 0.289 | 37.4% |
Control | 163 (0.422) | 171 (0.443) | 52 (0.135) | 497 (0.644) | 275 (0.356) | Â | |||||
Intron 8 | rs3751582 | ASD | G/A | 195 (0.548) | 126 (0.354) | 35 (0.098) | 0.013 | 516 (0.725) | 196 (0.275) | 0.131 | 34.0% |
Control | 217 (0.562) | 152 (0.394) | 17 (0.044) | 586 (0.759) | 186 (0.241) | Â | |||||